α-Naphthoflavone CAS: 604-59-1
MF: C19H12O2
MW: 272.30
An aryl hydrocarbon receptor inhibitor.

α-Naphthoflavone (CAS 604-59-1)

α-Naphthoflavone | CAS 604-59-1 is rated 5.0 out of 5 by 1.
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Alternate Names: 7,8-Benzoflavone
Application: α-Naphthoflavone is an aryl hydrocarbon receptor inhibitor
CAS Number: 604-59-1
Purity: ≥98%
Molecular Weight: 272.30
Molecular Formula: C19H12O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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α-Naphthoflavone is a naturally occurring compound found in Passiflora. α-Naphthoflavone is an aryl hydrocarbon receptor antagonist and inhibitor of CYP1A1 gene expression. Experiments show inhibitory properties towards cytochrome P450 enzymes, CYP1A1 (P4501A1) and CYP1A2 (P4501A2) (competetive binding) with stimulatory activities towards CYP3A4 (P4503A4) (selective binding). α-Naphthoflavone is an inhibitor of CYP19.


References

1. Dhawan, K., et al. 2004. J Ethnopharmacol. 94: 1-23. PMID: 15261959

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in methanol:ethyl acetate(2:3) (50 mg/ml), chloroform (slightly), sulfuric acid, and hot ethanol. Insoluble in water.
Storage :
Store at 4° C
Melting Point :
153-157° C (lit.)
Boiling Point :
~460.9° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.70 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
QL6250000
PubChem CID :
11790
MDL Number :
MFCD00004985
EC Number :
210-071-1
Beilstein Registry :
210494
SMILES :
C1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C4=CC=CC=C4C=C3

Download SDS (MSDS)

Certificate of Analysis

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α-Naphthoflavone (CAS 604-59-1) Product Citations

See how others have used α-Naphthoflavone (CAS 604-59-1). Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 28949811  Quinney, SK. et al. 2017. Fetal Pediatr Pathol. 36: 400-411.

PMID: # 26752525  Raggi, F. et al. 2016. PloS one. 11: e0146729.

PMID: # 15261959  Dhawan, K. et al. 2004. J Ethnopharmacol. 94: 1-23.

Citations 1 to 3 of 3 total
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Rated 5 out of 5 by from Sheu Sheu, ML. et al. (PubMed 26415004) reported that inhibition of aryl hydrocarbon receptor by -Naphthoflavone attenuates oxidative stress-related mesangial cell activation and macrophage infiltration and extracellular matrix accumulation in diabetic nephropathy. -SCBT Publication Review
Date published: 2015-03-28
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