CYP27A1 Activators
The chemical class of CYP27A1 Activator" includes compounds that can indirectly influence CYP27A1 function through their effects on cholesterol and bile acid metabolism. CYP27A1, being involved in the synthesis of bile acids from cholesterol, is influenced by changes in cholesterol levels and the homeostasis of bile acids. Compounds such as cholic acid, chenodeoxycholic acid, and ursodeoxycholic acid, as part of the bile acid pool, can potentially influence CYP27A1 activity through feedback mechanisms within the bile acid synthesis pathway.
Statin drugs like lovastatin, simvastatin, atorvastatin, and rosuvastatin, by inhibiting cholesterol synthesis, could indirectly affect CYP27A1 activity. The reduction in cholesterol levels by statins might influence the synthesis of bile acids, thereby modulating CYP27A1 activity. Other lipid-lowering agents such as fenofibrate, niacin, and ezetimibe, as well as omega-3 fatty acids, could also have an indirect impact on CYP27A1. These compounds, by altering lipid metabolism, can influence the substrates available for bile acid synthesis, potentially impacting CYP27A1 activity.Additionally, Vitamin D, with its role in calcium and lipid metabolism, might also indirectly affect CYP27A1 function.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cholic acid | 81-25-4 | sc-255020 sc-255020A sc-255020B sc-255020C sc-255020D | 25 g 100 g 500 g 1 kg 5 kg | $49.00 $123.00 $578.00 $1018.00 $4570.00 | 11 | |
A primary bile acid that might influence CYP27A1 activity through feedback mechanisms in bile acid synthesis. | ||||||
Chenodeoxycholic acid, free acid | 474-25-9 | sc-278835 sc-278835A | 1 g 5 g | $28.00 $117.00 | ||
Another primary bile acid, potentially affecting CYP27A1 through regulatory pathways in bile acid metabolism. | ||||||
Ursodeoxycholic acid | 128-13-2 | sc-204935 sc-204935A | 1 g 5 g | $52.00 $131.00 | 4 | |
A secondary bile acid used in cholesterol management, could indirectly affect CYP27A1 activity. | ||||||
Lovastatin | 75330-75-5 | sc-200850 sc-200850A sc-200850B | 5 mg 25 mg 100 mg | $29.00 $90.00 $339.00 | 12 | |
A statin that inhibits HMG-CoA reductase, potentially influencing CYP27A1 activity by altering cholesterol synthesis. | ||||||
Simvastatin | 79902-63-9 | sc-200829 sc-200829A sc-200829B sc-200829C | 50 mg 250 mg 1 g 5 g | $31.00 $89.00 $135.00 $443.00 | 13 | |
Another statin, might affect CYP27A1 indirectly through its impact on cholesterol levels and metabolism. | ||||||
Atorvastatin | 134523-00-5 | sc-337542A sc-337542 | 50 mg 100 mg | $257.00 $505.00 | 9 | |
A widely used statin, could impact CYP27A1 activity by modulating cholesterol biosynthesis. | ||||||
Rosuvastatin | 287714-41-4 | sc-481834 | 10 mg | $145.00 | 8 | |
A statin affecting cholesterol synthesis, potentially influencing CYP27A1 activity indirectly. | ||||||
Fenofibrate | 49562-28-9 | sc-204751 | 5 g | $41.00 | 9 | |
A fibrate drug that lowers lipid levels, could affect CYP27A1 indirectly by altering lipid metabolism. | ||||||
Nicotinic Acid | 59-67-6 | sc-205768 sc-205768A | 250 g 500 g | $62.00 $124.00 | 1 | |
Known to affect lipid levels, might influence CYP27A1 activity through its impact on cholesterol metabolism. | ||||||
Ezetimibe | 163222-33-1 | sc-205690 sc-205690A | 25 mg 100 mg | $96.00 $241.00 | 12 | |
Inhibits cholesterol absorption, potentially impacting CYP27A1 activity indirectly by altering cholesterol levels. | ||||||