CYP26A1 Activators

The chemicals listed here are not direct activators of CYP26A1 but may influence its activity through various indirect mechanisms. CYP26A1 is crucial for maintaining retinoic acid homeostasis, and any alteration in retinoic acid levels or signaling can potentially impact the enzyme's activity. Compounds like Citral, Flufenamic acid, and Raloxifene interact with retinoic acid metabolism or signaling pathways. By modulating the levels of retinoic acid or its signaling pathways, these compounds can indirectly influence the activity of CYP26A1, which is responsible for the catabolism of retinoic acid.

Antifungals like Ketoconazole and antiparasitics like Mebendazole are known to affect cytochrome P450 enzymes. While their primary targets are different, their influence on P450 enzymes could extend to CYP26A1, altering its activity indirectly. Drugs such as Nifedipine, Phenobarbital, Rifampicin, and Valproic Acid are known to modulate the activity of various cytochrome P450 enzymes. Phenobarbital, for instance, is a well-known inducer of certain P450 enzymes and might affect CYP26A1 indirectly. Rifampicin is another potent inducer of P450 enzymes and could similarly influence CYP26A1. Lastly, compounds like Tazarotene, a synthetic retinoid, may also affect CYP26A1 activity. As a compound related to retinoic acid, it could modulate the enzyme's activity by altering the substrate availability or through feedback mechanisms on the retinoic acid signaling pathways.