CXorf65 Activators
CXorf65 exhibits increased functional activity when specific cellular signaling pathways are modulated. One mechanism by which CXorf65 activation occurs is through the elevation of intracellular second messenger concentrations such as cAMP and cGMP. This elevation can result from the activation of adenylyl cyclase or inhibition of phosphodiesterases that normally degrade these cyclic nucleotides. The resulting high levels of cAMP or cGMP enhance the activity of protein kinases such as protein kinase A (PKA) or protein kinase G (PKG), which then phosphorylate target proteins, including CXorf65. Additionally, the intracellular calcium concentration is another determinant of CXorf65 activity, as calcium ionophores can raise the levels of this cation, which may activate calcium-dependent kinases capable of phosphorylating and activating CXorf65.
Moreover, the modulation of specific protein kinases and their associated signaling cascades plays a pivotal role in regulating CXorf65 activity. For instance, agents that activate protein kinase C (PKC) or inhibit glycogen synthase kinase 3 (GSK-3) can alter the phosphorylation state of various proteins within the cell, potentially leading to the activation of CXorf65. Also, cellular stress responses can trigger a cascade of signaling events that culminate in the activation of stress-activated protein kinases, which, in turn, might phosphorylate and activate CXorf65.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
Non-selective inhibitor of phosphodiesterases, prevents cAMP degradation, indirectly upholding cAMP-mediated activation of CXorf65 through sustained protein kinase A signaling. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Calcium ionophore that increases intracellular calcium levels, potentially activating calcium-dependent protein kinases which can phosphorylate and activate CXorf65. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Activates protein kinase C (PKC), which may lead to phosphorylation and subsequent activation of CXorf65 as part of intracellular signaling cascades. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
β-adrenergic agonist that stimulates adenylyl cyclase via G protein-coupled receptor signaling, increasing intracellular cAMP and activating PKA, which may lead to the activation of CXorf65. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A calcium ionophore that increases intracellular calcium and can activate downstream kinases, potentially leading to the activation of CXorf65. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Selective phosphodiesterase 4 inhibitor, prevents cAMP breakdown, potentiating PKA activity and possible phosphorylation and activation of CXorf65. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Cell-permeable cAMP analog that directly activates PKA, potentially leading to the phosphorylation and activation of CXorf65 through cAMP-dependent pathways. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Inhibits glycogen synthase kinase 3 (GSK-3), potentially leading to altered phosphorylation states of proteins and activation of CXorf65 indirectly through this kinase inhibition. | ||||||
Zaprinast (M&B 22948) | 37762-06-4 | sc-201206 sc-201206A | 25 mg 100 mg | $105.00 $250.00 | 8 | |
Phosphodiesterase 5 inhibitor, increases cGMP levels, which may lead to the activation of PKG and possible cross-activation of CXorf65 through downstream signaling. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Inhibits protein synthesis at the level of peptide elongation and can activate stress-activated protein kinases, which may lead to the activation of CXorf65 in response to cellular stress signals. | ||||||