CTRP2 is a multifaceted protein with roles in various cellular processes, including but not limited to energy metabolism, cell signaling, and stress response. The inhibitors targeting CTRP2 often affect its activity indirectly through the modulation of pathways in which CTRP2 is implicated. For example, AICAR is an AMPK that induces an energy-starvation condition, thus interfering with CTRP2 signaling. Similarly, Wortmannin and LY294002 inhibit PI3K, which in turn can influence CTRP2's role in cellular survival and signaling. Rapamycin targets mTOR, a key player in several pathways where CTRP2 is active. Inhibitors like PD98059 and U0126 focus on MEK and therefore have the to disrupt ERK pathways, where CTRP2 may also play a role. SB203580 inhibits p38 MAPK, affecting CTRP2's function in cellular stress responses.
In the context of calcium signaling, both KN-93, a CaMKII inhibitor, and BAPTA-AM, a calcium chelator, can impact CTRP2 activity. SP600125 inhibits JNK, thereby affecting CTRP2's role in stress responses and cellular survival. Akti-1/2, which inhibits Akt, affects CTRP2 signaling in pathways related to cell survival and growth. Lastly, Genistein, a tyrosine kinase inhibitor, can disturb CTRP2's interactions with enzymes requiring phosphorylation. Collectively, these chemicals offer a toolbox of pharmacological agents that serve to inhibit CTRP2 directly or indirectly by targeting the specific pathways in which this protein is involved. They operate via diverse mechanisms, from kinase inhibition to ion chelation, and provide a comprehensive approach to understanding how CTRP2 function can be modulated.
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Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Inhibits PI3K, thus affecting the pathways where CTRP2 is crucial for cellular survival and signaling. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
Inhibits PI3K, which can consequently affect CTRP2-mediated cellular processes. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Inhibits mTOR, a key regulator in pathways where CTRP2 functions, thus affecting CTRP2's signaling capabilities. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
MEK inhibitor that can disrupt ERK pathways, potentially affecting CTRP2-dependent cellular processes. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
Inhibits p38 MAPK, impacting CTRP2’s role in cellular stress responses. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $178.00 | 25 | |
Inhibits CaMKII, and can affect CTRP2 in calcium signaling pathways. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $449.00 | 61 | |
Calcium chelator that can inhibit CTRP2’s function in calcium-dependent pathways. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
JNK inhibitor which can impact CTRP2's role in cellular stress and survival. | ||||||
Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 | 612847-09-3 | sc-202048 sc-202048A | 1 mg 5 mg | $204.00 $265.00 | 29 | |
Inhibits Akt, impacting CTRP2 signaling in pathways related to cell survival and growth. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Tyrosine kinase inhibitor that can disrupt CTRP2's interaction with enzymes requiring phosphorylation. |