Date published: 2025-12-6

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CTLA-4 Antibodies

Santa Cruz Biotechnology offers a broad range of CTLA-4 monoclonal antibodies for immunology and cancer biology research. CTLA-4 monoclonal antibodies are validated for western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). CTLA-4, or cytotoxic T-lymphocyte-associated protein 4, is a critical immune checkpoint that plays a vital role in regulating T cell activation and maintaining immune homeostasis. By inhibiting T cell responses, CTLA-4 is essential for preventing autoimmunity and promoting tolerance to self-antigens. The importance of CTLA-4 in cancer therapy has been demonstrated by the development of CTLA-4 inhibitors, which have shown promise in enhancing anti-tumor immunity. Researchers can investigate immune regulation mechanisms using specific CTLA-4 detection methods. Understanding CTLA-4 function continues to reveal new insights into immune system regulation and potential therapeutic strategies. Current studies focusing on CTLA-4 are advancing our knowledge of immune checkpoint pathways and their role in disease. Santa Cruz Biotechnology monoclonal antibodies for CTLA-4 support researchers worldwide in advancing immunotherapy and cancer treatment breakthroughs.

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CTLA-4 Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

CTLA-4 Antibody (F-8)

sc-376016mouse IgG1 κ195-223 (h)WB, IP, IF, IHC(P), ELISAm, r, h
59
(22)

CTLA-4 Antibody (1B8)

sc-18829A. hamster IgGN/AIP, IF, IHC(P), FCMm

new

(2)

CTLA-4 CRISPR Knockout, HDR and Double Nickase Plasmids

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

CTLA-4 CRISPR/Cas9 KO Plasmid (h)

sc-400948hGene KnockoutGFP0
(0)

CTLA-4 HDR Plasmid (h)

sc-400948-HDRhHomology Directed RepairPuromycin0
(0)

CTLA-4 Double Nickase Plasmid (h)

sc-400948-NIChGene KnockoutPuromycin0
(0)

CTLA-4 Double Nickase Plasmid (h2)

sc-400948-NIC-2hGene KnockoutPuromycin0
(0)

CTLA-4 CRISPR/Cas9 KO Plasmid (m)

sc-419533mGene KnockoutGFP0
(0)

CTLA-4 HDR Plasmid (m)

sc-419533-HDRmHomology Directed RepairPuromycin0
(0)

CTLA-4 Double Nickase Plasmid (m)

sc-419533-NICmGene KnockoutPuromycin0
(0)

CTLA-4 Double Nickase Plasmid (m2)

sc-419533-NIC-2mGene KnockoutPuromycin0
(0)

CTLA-4 CRISPR Activation Products

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

CTLA-4 CRISPR Activation Plasmid (h)

sc-400948-ACThGene ActivationPuro, Blast, Hygro0
(0)

CTLA-4 CRISPR Activation Plasmid (h2)

sc-400948-ACT-2hGene ActivationPuro, Blast, Hygro0
(0)

CTLA-4 Lentiviral Activation Particles (h)

sc-400948-LAChGene ActivationPuro, Blast, Hygro0
(0)

CTLA-4 Lentiviral Activation Particles (h2)

sc-400948-LAC-2hGene ActivationPuro, Blast, Hygro0
(0)

CTLA-4 CRISPR Activation Plasmid (m)

sc-419533-ACTmGene ActivationPuro, Blast, Hygro0
(0)

CTLA-4 CRISPR Activation Plasmid (m2)

sc-419533-ACT-2mGene ActivationPuro, Blast, Hygro0
(0)

CTLA-4 Lentiviral Activation Particles (m)

sc-419533-LACmGene ActivationPuro, Blast, Hygro0
(0)

CTLA-4 Lentiviral Activation Particles (m2)

sc-419533-LAC-2mGene ActivationPuro, Blast, Hygro0
(0)

CTLA-4 siRNA, shRNA Plasmid and shRNA Lentiviral Particle Gene Silencers

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

CTLA-4 siRNA (h)

sc-42766hGene SilencingN/A
2
(1)

CTLA-4 shRNA Plasmid (h)

sc-42766-SHhGene SilencingPuromycin
2
(1)

CTLA-4 shRNA (h) Lentiviral Particles

sc-42766-VhGene SilencingPuromycin
2
(1)

CTLA-4 siRNA (m)

sc-42767mGene SilencingN/A0
(1)

CTLA-4 shRNA Plasmid (m)

sc-42767-SHmGene SilencingPuromycin0
(1)

CTLA-4 shRNA (m) Lentiviral Particles

sc-42767-VmGene SilencingPuromycin0
(1)