CTLA-4 Inhibitors
CTLA-4 inhibitors comprise a distinctive chemical class celebrated for their pivotal role in orchestrating immune responses within the intricate milieu of the human body. Central to their mechanism is the selective targeting of the cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) protein, an imperative regulator prominently stationed on the surface of T cells – a subclass of white blood cells crucial to adaptive immunity. Renowned for its adeptness in tempering immune reactions, CTLA-4 exerts its influence by curbing the activation of T cells. The emergence of CTLA-4 inhibitors introduces a paradigm shift by harnessing this inherent biological interplay. These inhibitors are artfully fashioned to engage with the CTLA-4 receptor, thereby instigating an interruption of its inhibitory signaling cascade. This disruption, in turn, has the ability to tip the scales in favor of heightened immune activation, possibly engendering a more robust and targeted immune response.
Within the landscape of immunology, the class of CTLA-4 inhibitors beckons with its nuanced intrigue and far-reaching implications. As these inhibitors interface with a pivotal checkpoint in the immunoregulatory network, their distinctive chemical makeup assumes significance as a subject of fervent scientific exploration. Notably, CTLA-4 inhibitors' intricate mode of action has sparked scientific fervor for its role in modulating diverse biological processes beyond the scope of direct immune response modulation. The controlled perturbation of immune checkpoints, facilitated by these inhibitors, introduces a captivating avenue for understanding immune homeostasis and its dysregulation in various disease contexts.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin, a flavonoid, is known for its anti-inflammatory properties and may indirectly influence CTLA-4 through its regulatory effects on cytokine profiles, possibly reducing the immunosuppressive action of CTLA-4 on T cells. | ||||||
Silymarin group, mixture of isomers | 65666-07-1 | sc-301806 | 50 g | $325.00 | ||
Silymarin affects cytokine expression and immune responses, potentially reducing CTLA-4-mediated signaling by altering the balance of T cell activation and inhibition through immune regulatory mechanisms. | ||||||
Piperine | 94-62-2 | sc-205809 sc-205809A | 5 g 25 g | $37.00 $146.00 | 3 | |
Piperine modulates several signaling pathways including those involved in T cell activation. It could indirectly decrease the functional activity of CTLA-4 by enhancing the proliferative response of T cells and reducing immune suppression. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
A major component of green tea, known to affect T cell activity and cytokine production. Its influence on these pathways may indirectly reduce CTLA-4 expression or modulate its activity, impacting T cell responses and immune checkpoint regulation. | ||||||
Kaempferol | 520-18-3 | sc-202679 sc-202679A sc-202679B | 25 mg 100 mg 1 g | $99.00 $216.00 $510.00 | 11 | |
Kaempferol influences immune regulation through its effects on cytokine signaling, potentially altering CTLA-4 mediated T cell inhibition indirectly by modulating the immune environment and T cell activation. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
As an isoflavone with immunomodulatory properties, Genistein can affect T cell function and cytokine production, possibly leading to an indirect reduction in CTLA-4 activity by changing the immune checkpoint dynamics. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin impacts immune cell function and cytokine release, which might translate to an indirect effect on CTLA-4 expression and function by altering T cell activation states and immune checkpoint interactions. | ||||||
Luteolin | 491-70-3 | sc-203119 sc-203119A sc-203119B sc-203119C sc-203119D | 5 mg 50 mg 500 mg 5 g 500 g | $27.00 $51.00 $101.00 $153.00 $1925.00 | 40 | |
Luteolin affects multiple signaling pathways related to inflammation and immune response, potentially decreasing CTLA-4 mediated inhibition by modulating T cell activation and cytokine profiles. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $33.00 $214.00 $734.00 $1151.00 $2348.00 $3127.00 $5208.00 | 22 | |
Apigenin has demonstrated effects on immune cell regulation and cytokine production, potentially impacting CTLA-4 functionality indirectly by altering the immunological environment and checkpoint interactions. | ||||||