Date published: 2026-6-9

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Luteolin (CAS 491-70-3)

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Alternate Names:
Luteolin is also known as 3′,4′,5,7-Tetrahydroxyflavone.
Application:
Luteolin is an inhibitor of LPS-induced TNF-α, IL-6 and inducible nitric oxide production and blocker of NF-κB and AP-1 activation.
CAS Number:
491-70-3
Purity:
≥98%
Molecular Weight:
286.24
Molecular Formula:
C15H10O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Luteolin is an antioxidant flavonoid and a free radical scavenger. It inhibits rat liver cytosolic glutathione S-transferase activity and soybean and reticulocyte 15-LO (15-lipoxygenases). Luteolin also shows cytotoxic effects on Raji lymphoma cells. Incubation of the non-tumor cell line C3H10T½CL8 with Luteolin results in induction of p53 accumulation and apoptosis, with apoptosis occurring at the G2/M phase of the cell cycle.


Luteolin (CAS 491-70-3) References

  1. Inhibition of matrix-proteases by polyphenols: chemical insights for anti-inflammatory and anti-invasion drug design.  |  Sartor, L., et al. 2002. Biochem Pharmacol. 64: 229-37. PMID: 12123743
  2. Luteolin as an anti-inflammatory and anti-allergic constituent of Perilla frutescens.  |  Ueda, H., et al. 2002. Biol Pharm Bull. 25: 1197-202. PMID: 12230117
  3. Inhibition of 15-lipoxygenases by flavonoids: structure-activity relations and mode of action.  |  Sadik, CD., et al. 2003. Biochem Pharmacol. 65: 773-81. PMID: 12628491
  4. Luteolin prevents irinotecan-induced intestinal mucositis in mice through antioxidant and anti-inflammatory properties.  |  Boeing, T., et al. 2020. Br J Pharmacol. 177: 2393-2408. PMID: 31976547
  5. Luteolin alleviates cognitive impairment in Alzheimer's disease mouse model via inhibiting endoplasmic reticulum stress-dependent neuroinflammation.  |  Kou, JJ., et al. 2022. Acta Pharmacol Sin. 43: 840-849. PMID: 34267346
  6. Luteolin Inhibits Breast Cancer Stemness and Enhances Chemosensitivity through the Nrf2-Mediated Pathway.  |  Tsai, KJ., et al. 2021. Molecules. 26: PMID: 34770867
  7. Exploration of the mechanism of luteolin against ischemic stroke based on network pharmacology, molecular docking and experimental verification.  |  Dong, R., et al. 2021. Bioengineered. 12: 12274-12293. PMID: 34898370
  8. Luteolin relieves lung cancer-induced bone pain by inhibiting NLRP3 inflammasomes and glial activation in the spinal dorsal horn in mice.  |  Zhou, YS., et al. 2022. Phytomedicine. 96: 153910. PMID: 35026502
  9. Radioprotective effect of antioxidative flavonoids in gamma-ray irradiated mice.  |  Shimoi, K., et al. 1994. Carcinogenesis. 15: 2669-72. PMID: 7955124
  10. Effects of gamma-linolenic acid, flavonoids, and vitamins on cytotoxicity and lipid peroxidation.  |  Ramanathan, R., et al. 1994. Free Radic Biol Med. 16: 43-8. PMID: 8299995
  11. Flavonoids activate wild-type p53.  |  Plaumann, B., et al. 1996. Oncogene. 13: 1605-14. PMID: 8895505
  12. Antioxidant and chelating properties of flavonoids.  |  Korkina, LG. and Afanas'ev, IB. 1997. Adv Pharmacol. 38: 151-63. PMID: 8895808

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Luteolin, 5 mg

sc-203119
5 mg
$27.00

Luteolin, 50 mg

sc-203119A
50 mg
$51.00

Luteolin, 500 mg

sc-203119B
500 mg
$101.00

Luteolin, 5 g

sc-203119C
5 g
$153.00

Luteolin, 500 g

sc-203119D
500 g
$1925.00