CTF8 Activators
CTF8, or Chromosome Transmission Fidelity Factor 8, is a protein that in humans is encoded by the CHTF8 gene. It's a component of the CTF18-RFC (Replication Factor C) complex, which plays a crucial role in sister chromatid cohesion and DNA replication.The sister chromatid cohesion process is essential during cell division, ensuring that each new cell receives an accurate copy of the genome. The CTF18-RFC complex, including CTF8, helps load the cohesin complex onto DNA, facilitating the cohesion of sister chromatids.
CTF8 is also involved in the DNA damage response. It contributes to maintaining genome stability by promoting efficient DNA repair. When DNA damage occurs, the CTF18-RFC complex helps facilitate the DNA repair machinery's access to the damaged site.Further, CTF8 and its associated CTF18-RFC complex are critical for the S phase checkpoint. This is a control mechanism that ensures DNA replication is complete before the cell enters mitosis, thus inhibiting the propagation of errors to daughter cells.While the precise mechanisms of CTF8 function continue to be studied, it's clear that it plays a vital role in maintaining genomic integrity. Alterations in CTF8 or other components of the CTF18-RFC complex could potentially lead to chromosomal abnormalities, contributing to various diseases, including cancer.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine can inhibit DNA methyltransferase, potentially leading to the demethylation and activation of certain genes involved in cell cycle regulation. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid influences cell differentiation and proliferation, which may involve upregulation of genes necessary for these processes, such as CTF8. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
Hydroxyurea inhibits ribonucleotide reductase, causing DNA replication stress that could stimulate the expression of DNA repair and replication genes. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Camptothecin inhibits topoisomerase I, leading to DNA damage and potentially inducing expression of genes involved in DNA repair, including CTF8. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide inhibits topoisomerase II, causing DNA damage and can lead to the induction of DNA repair genes as a cellular response. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin causes DNA crosslinking, which may upregulate the expression of genes involved in DNA repair pathways. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
Methotrexate is a dihydrofolate reductase inhibitor that can lead to cell cycle arrest at the S-phase, potentially affecting the expression of S-phase-specific genes. | ||||||
Aphidicolin | 38966-21-1 | sc-201535 sc-201535A sc-201535B | 1 mg 5 mg 25 mg | $84.00 $306.00 $1104.00 | 30 | |
Aphidicolin is a DNA polymerase inhibitor that can cause replication stress, possibly inducing the expression of genes related to DNA replication and repair. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate, a histone deacetylase inhibitor, can change gene expression patterns, which might include genes like CTF8. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
β-estradiol can modulate gene expression through estrogen receptor signaling, potentially influencing the expression of genes associated with cell cycle regulation. | ||||||