CSB Activators
CSB Activators represent a class of chemical compounds that are associated with the activation or modulation of the CSB protein, also known as Cockayne syndrome group B protein. CSB is a crucial component of the transcription-coupled nucleotide excision repair (TC-NER) pathway, which is responsible for repairing DNA damage that occurs during transcription. This repair mechanism is vital for maintaining the integrity of the genome and preventing mutations and other cellular dysfunctions caused by DNA damage.
CSB activators typically interact with the CSB protein, leading to conformational changes or alterations in its activity. These interactions are believed to enhance or regulate the ability of CSB to recognize and repair DNA lesions encountered during transcription. The CSB protein plays a significant role in removing a wide range of DNA lesions, such as ultraviolet (UV)-induced photoproducts and bulky adducts caused by environmental genotoxins. By facilitating the repair of DNA damage specifically during transcription, CSB activators contribute to the overall genomic stability and cellular health. The precise mechanisms and applications of these activators are still areas of active research in the field of DNA repair and genomic maintenance, as understanding the regulation of CSB protein activity is essential for comprehending the molecular processes underlying various diseases and conditions associated with impaired DNA repair.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol can enhance DNA repair mechanisms, potentially indirectly activating CSB by upregulating the cellular response to DNA damage. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin is known to modulate various molecular targets involved in DNA repair processes, possibly influencing CSB activity indirectly. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
DL-Sulforaphane may indirectly activate CSB by modulating antioxidant response elements and DNA repair pathways. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin, a flavonoid, can modulate DNA damage response, potentially influencing CSB activity indirectly. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein, an isoflavone, can impact DNA repair pathways, potentially having an indirect effect on CSB activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
This green tea polyphenol may indirectly influence CSB activity by affecting signaling pathways involved in DNA repair. | ||||||
Ellagic Acid, Dihydrate | 476-66-4 | sc-202598 sc-202598A sc-202598B sc-202598C | 500 mg 5 g 25 g 100 g | $57.00 $93.00 $240.00 $713.00 | 8 | |
Ellagic acid, found in berries and nuts, may have an indirect impact on CSB activity through its influence on DNA damage response and repair mechanisms. | ||||||
(+)-α-Tocopherol | 59-02-9 | sc-214454 sc-214454A sc-214454B | 10 g 25 g 100 g | $42.00 $61.00 $138.00 | ||
As an antioxidant, (+)-α-Tocopherol (Vitamin E) may indirectly influence CSB activity by reducing oxidative DNA damage, thus modulating DNA repair pathways. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $33.00 $73.00 $265.00 $112.00 | 34 | |
N-Acetyl-L-cysteine, known for its antioxidant properties, might have an indirect effect on CSB by altering the redox state and DNA repair mechanisms. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic Acid can influence gene expression and cellular differentiation, potentially having an indirect effect on CSB through altered transcription regulation. | ||||||