CS1 Inhibitors
CS1, also known as SLAMF7 (Signaling Lymphocytic Activation Molecule Family member 7), is a transmembrane glycoprotein primarily expressed on the surface of natural killer (NK) cells, plasma cells, and subsets of T cells. It plays a crucial role in regulating immune responses, particularly in mediating cell-to-cell interactions and modulating the function of immune cells. CS1 functions as a co-stimulatory molecule, promoting NK cell activation and cytotoxicity upon engagement with its ligands, including CD48 and CD2 on target cells. Additionally, CS1 is involved in the regulation of plasma cell survival and differentiation, contributing to the maintenance of humoral immunity.
Inhibition of CS1 entails disrupting its signaling pathways or interfering with its interactions with ligands, thereby attenuating immune responses mediated by CS1-expressing cells. Several mechanisms of inhibition have been proposed, including blockade of CS1 ligand binding, downregulation of CS1 expression, and interference with downstream signaling events. Strategies targeting CS1 inhibition have shown promise in modulating immune responses in various disease contexts, including autoimmune diseases, hematologic malignancies, and solid tumors. Further elucidation of the precise mechanisms underlying CS1 inhibition may provide insights into the development of novel approaches for immune-related disorders.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Pomalidomide | 19171-19-8 | sc-364593 sc-364593A sc-364593B sc-364593C sc-364593D sc-364593E | 5 mg 10 mg 50 mg 100 mg 500 mg 1 g | $100.00 $143.00 $312.00 $468.00 $1248.00 $1997.00 | 1 | |
Pomalidomide inhibits CS1 by modulating the NF-κB pathway. Acting as an immunomodulatory drug, Pomalidomide alters NF-κB signaling, leading to indirect inhibition of CS1 and influencing downstream cellular processes associated with immune responses. | ||||||
Thalidomide | 50-35-1 | sc-201445 sc-201445A | 100 mg 500 mg | $111.00 $357.00 | 8 | |
Thalidomide inhibits CS1 indirectly by modulating the NF-κB pathway. As an immunomodulatory drug, Thalidomide influences NF-κB signaling, leading to indirect inhibition of CS1 and modulation of downstream cellular processes associated with immune regulation. | ||||||
Lenalidomide | 191732-72-6 | sc-218656 sc-218656A sc-218656B | 10 mg 100 mg 1 g | $50.00 $374.00 $2071.00 | 18 | |
Lenalidomide inhibits CS1 by modulating the NF-κB pathway. As an immunomodulatory drug, Lenalidomide alters NF-κB signaling, leading to indirect inhibition of CS1 and influencing downstream cellular processes associated with immune responses. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin inhibits CS1 indirectly by suppressing the STAT3 pathway. Through modulation of STAT3 phosphorylation, Curcumin influences downstream signaling events associated with CS1, leading to indirect inhibition and modulation of cellular processes linked to immune responses. | ||||||
Ibrutinib | 936563-96-1 | sc-483194 | 10 mg | $156.00 | 5 | |
Ibrutinib inhibits CS1 by targeting the B-cell receptor (BCR) pathway. As a Bruton's tyrosine kinase (BTK) inhibitor, Ibrutinib interferes with BCR signaling, leading to direct inhibition of CS1 and modulation of downstream cellular processes associated with B-cell function. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Bortezomib inhibits CS1 by targeting the proteasome pathway. As a proteasome inhibitor, Bortezomib influences protein degradation, leading to indirect inhibition of CS1 and modulation of downstream cellular processes associated with protein homeostasis. | ||||||
CC-122 | 1015474-32-4 | sc-507488 | 5 mg | $420.00 | ||
Lenalidomide analog CC-122 inhibits CS1 by modulating the NF-κB pathway. Similar to Lenalidomide, CC-122 alters NF-κB signaling, leading to indirect inhibition of CS1 and influencing downstream cellular processes associated with immune responses. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
Bay 11-7082 inhibits CS1 indirectly by suppressing the NF-κB pathway. Through modulation of IκBα phosphorylation, Bay 11-7082 influences NF-κB signaling, leading to indirect inhibition of CS1 and modulation of downstream cellular processes associated with immune responses. | ||||||
Auranofin | 34031-32-8 | sc-202476 sc-202476A sc-202476B | 25 mg 100 mg 2 g | $153.00 $214.00 $4000.00 | 39 | |
Auranofin inhibits CS1 indirectly by suppressing the NF-κB pathway. Through modulation of IκBα phosphorylation, Auranofin influences NF-κB signaling, leading to indirect inhibition of CS1 and modulation of downstream cellular processes associated with immune responses. | ||||||