CS1 Activators
CS1, also referred to as SLAMF7 (Signaling Lymphocytic Activation Molecule Family member 7), is a cell surface receptor predominantly expressed on natural killer (NK) cells, subsets of T cells, and plasma cells. This transmembrane glycoprotein plays a pivotal role in modulating immune responses by mediating cell-to-cell interactions and regulating the function of immune cells. CS1 serves as a co-stimulatory molecule, facilitating NK cell activation and cytotoxicity upon engagement with its ligands, such as CD48 and CD2 on target cells. Additionally, CS1 is involved in the regulation of plasma cell survival and differentiation, contributing to the maintenance of humoral immunity.
Activation of CS1 entails triggering signaling cascades upon ligand binding, leading to cellular responses associated with immune activation. Upon interaction with its ligands, CS1 undergoes conformational changes that initiate intracellular signaling pathways. These pathways typically involve the recruitment and activation of intracellular signaling molecules, such as Src family kinases and adaptor proteins, which propagate downstream signals. Activation of CS1 results in the activation of NK cells, leading to enhanced cytotoxicity against target cells and secretion of pro-inflammatory cytokines. Furthermore, engagement of CS1 on plasma cells promotes their survival and differentiation, thereby augmenting antibody production and humoral immune responses. Elucidating the precise mechanisms of CS1 activation is crucial for understanding its role in immune regulation and may provide insights into the development of immunomodulatory strategies for various diseases.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates CS1 indirectly by activating the PKC pathway. Through PKC activation, TPA influences downstream signaling events associated with CS1, leading to indirect activation and modulation of cellular processes linked to immune responses. | ||||||
R-848 | 144875-48-9 | sc-203231 sc-203231A sc-203231B sc-203231C | 5 mg 25 mg 100 mg 500 mg | $102.00 $306.00 $510.00 $1559.00 | 12 | |
R-848 activates CS1 by activating the Toll-like receptor (TLR) pathway. Through TLR activation, Resiquimod induces immune responses, leading to direct activation of CS1 and modulation of downstream cellular processes associated with TLR-mediated immune signaling. | ||||||
Phorbol-12,13-dibutyrate | 37558-16-0 | sc-202285 | 1 mg | $124.00 | 3 | |
PDBu activates CS1 indirectly by activating the PKC pathway. Through PKC activation, PDBu influences downstream signaling events associated with CS1, leading to indirect activation and modulation of cellular processes linked to immune responses. | ||||||
1α,25-Dihydroxyvitamin D3 | 32222-06-3 | sc-202877B sc-202877A sc-202877C sc-202877D sc-202877 | 50 µg 1 mg 5 mg 10 mg 100 µg | $220.00 $645.00 $1000.00 $1500.00 $440.00 | 32 | |
1,25-Dihydroxyvitamin D3 activates CS1 by modulating the vitamin D receptor (VDR) pathway. Through VDR activation, 1,25-Dihydroxyvitamin D3 influences downstream signaling events associated with CS1, leading to direct activation and modulation of cellular processes linked to immune responses. | ||||||
Imiquimod | 99011-02-6 | sc-200385 sc-200385A | 100 mg 500 mg | $67.00 $284.00 | 6 | |
Imiquimod activates CS1 by activating the Toll-like receptor (TLR) pathway. Through TLR activation, Imiquimod induces immune responses, leading to direct activation of CS1 and modulation of downstream cellular processes associated with TLR-mediated immune signaling. | ||||||
Leflunomide | 75706-12-6 | sc-202209 sc-202209A | 10 mg 50 mg | $20.00 $83.00 | 5 | |
Leflunomide activates CS1 by modulating the mitogen-activated protein kinase (MAPK) pathway. Through MAPK pathway modulation, Leflunomide influences downstream signaling events associated with CS1, leading to direct activation and modulation of cellular processes linked to immune responses. | ||||||
9-cis-Retinoic acid | 5300-03-8 | sc-205589 sc-205589B sc-205589C sc-205589D sc-205589A | 1 mg 25 mg 250 mg 500 mg 5 mg | $71.00 $424.00 $3121.00 $5722.00 $148.00 | 10 | |
9-cis-Retinoic Acid activates CS1 by modulating the retinoic acid receptor (RAR) pathway. Through RAR activation, 9-cis-Retinoic Acid influences downstream signaling events associated with CS1, leading to direct activation and modulation of cellular processes linked to immune responses. | ||||||
Calcipotriol | 112965-21-6 | sc-203537 sc-203537A | 10 mg 50 mg | $203.00 $832.00 | 4 | |
Calcipotriol activates CS1 by modulating the vitamin D receptor (VDR) pathway. Through VDR activation, Calcipotriol influences downstream signaling events associated with CS1, leading to direct activation and modulation of cellular processes linked to immune responses. | ||||||