Molecular structure of CC-122, CAS Number: 1015474-32-4
CC-122 (CAS 1015474-32-4)
Alternate Names:
3-(5-amino-2-methyl-4-oxo-3(4H)-quinazolinyl)-2,6-piperidinedione; Avadomide
CAS Number:
1015474-32-4
Molecular Weight:
286.3
Molecular Formula:
C14H14N4O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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CC-122 (CAS 1015474-32-4) References
- Differentiation of antiinflammatory and antitumorigenic properties of stabilized enantiomers of thalidomide analogs. | Jacques, V., et al. 2015. Proc Natl Acad Sci U S A. 112: E1471-9. PMID: 25775521
- CC-122, a pleiotropic pathway modifier, mimics an interferon response and has antitumor activity in DLBCL. | Hagner, PR., et al. 2015. Blood. 126: 779-89. PMID: 26002965
- Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS. | Krönke, J., et al. 2015. Nature. 523: 183-188. PMID: 26131937
- Thalidomide analog CC-122 induces a refractory state in monocytes from patients with diffuse large B cell lymphoma. | Cubillos-Zapata, C., et al. 2017. Leuk Lymphoma. 58: 1999-2001. PMID: 28093007
- CC-122 immunomodulatory effects in refractory patients with diffuse large B-cell lymphoma. | Cubillos-Zapata, C., et al. 2016. Oncoimmunology. 5: e1231290. PMID: 28255524
- Genome-wide CRISPR screens reveal genetic mediators of cereblon modulator toxicity in primary effusion lymphoma. | Patil, A., et al. 2019. Blood Adv. 3: 2105-2117. PMID: 31300418
- A Novel Drug, CC-122, Inhibits Tumor Growth in Hepatocellular Carcinoma through Downregulation of an Oncogenic TCF-4 Isoform. | Tomimaru, Y., et al. 2019. Transl Oncol. 12: 1345-1356. PMID: 31352197
- A Cereblon Modulator CC-885 Induces CRBN- and p97-Dependent PLK1 Degradation and Synergizes with Volasertib to Suppress Lung Cancer. | Li, L., et al. 2020. Mol Ther Oncolytics. 18: 215-225. PMID: 32728610
- Deciphering the mechanisms of CC-122 resistance in DLBCL via a genome-wide CRISPR screen. | Mo, Z., et al. 2021. Blood Adv. 5: 2027-2039. PMID: 33847741
Inhibitor of:
CS1, DCAF15, DCAF17, Dcun1D1, FBXO38, FBXO48, Rbx1, TRIM34B, and VE-cadherin.Activator of:
Aiolos, and Cdc53.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CC-122, 5 mg | sc-507488 | 5 mg | $420.00 |