CRSP77 Activators
CRSP77 activators are a distinctive class of small molecules that have garnered significant attention in the realm of chemical biology and molecular research. These compounds are characterized by their unique ability to modulate the activity of CRSP77, a specific protein or enzyme within the cellular machinery. CRSP77, which stands for Coactivator-Dependent RNA Polymerase II Transcription Complex Subunit 77, is an integral component of the transcriptional machinery responsible for regulating gene expression. It plays a pivotal role in facilitating the initiation and elongation of RNA synthesis during transcription. CRSP77 activators are designed to interact with this protein, either enhancing or inhibiting its function, which in turn has profound implications for the regulation of gene expression.
The mechanism of action of CRSP77 activators is intricate and multifaceted. These small molecules are meticulously designed to bind to specific sites on CRSP77, thereby influencing its conformation and function. Depending on their chemical structure and binding affinity, CRSP77 activators can either enhance the recruitment of transcription factors and coactivators to gene promoters, leading to increased gene transcription, or they can disrupt the interaction between CRSP77 and other essential transcriptional components, resulting in reduced gene expression
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Activates adenylate cyclase, increasing cAMP levels. This activates PKA, which may phosphorylate proteins interacting with or regulating CRSP77, thus influencing its activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
A potent activator of PKC. PKC activation modulates several pathways that might intersect with CRSP77, potentially altering its activity through phosphorylation or modulation of interacting proteins. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Inhibits GSK-3, impacting Wnt signaling components, possibly affecting proteins that indirectly regulate CRSP77 activity. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
A histone deacetylase inhibitor, it alters chromatin structure and gene expression, influencing gene expression patterns of proteins upstream or parallel to CRSP77, thereby modifying its activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Inhibits the mTOR pathway, involved in cell growth and proliferation. This inhibition leads to changes in cellular signaling networks that might indirectly affect CRSP77 activity. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
A selective inhibitor of the TGF-β receptor. Affects the SMAD signaling pathway, which might intersect with CRSP77 regulatory mechanisms. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A PI3K inhibitor. Inhibition of PI3K affects the AKT signaling pathway, implicated in various cellular processes, and can indirectly influence CRSP77 activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
An inhibitor of MEK in the MAPK/ERK pathway. Modulates the pathway, potentially affecting proteins that interact with or regulate CRSP77. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
An inhibitor of JNK in the MAPK pathway. JNK inhibition can lead to altered signaling dynamics in pathways potentially involving CRSP77. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
A potent inhibitor of PI3K. By modulating PI3K/AKT pathway activity, it can indirectly influence the activity of CRSP77 or its associated proteins. | ||||||