CRIM1 Activators
CRIM1 Activators belong to a distinct class of chemical compounds designed to modulate the activity of the Cysteine-Rich Motor Neuron 1 (CRIM1) protein. CRIM1 is a large, multi-domain transmembrane protein that plays a pivotal role in various cellular processes, including embryonic development, tissue homeostasis, and cell signaling. It is involved in critical mechanisms such as cell adhesion, angiogenesis, and the regulation of various growth factors. CRIM1's functions are essential for the proper development of various organ systems, making it a promising target for scientific research. CRIM1 activators are compounds designed to enhance the protein's activity or expression, potentially leading to a variety of cellular and molecular effects.
Chemical compounds categorized as CRIM1 activators typically interact with specific sites on the CRIM1 protein, either by binding directly to CRIM1 or by influencing downstream signaling pathways. By modulating CRIM1, these activators may impact fundamental cellular processes like cell proliferation, differentiation, and tissue regeneration. The development and study of CRIM1 activators can significantly contribute to our understanding of the molecular mechanisms underlying these processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline | 1062368-24-4 | sc-476297 | 5 mg | $240.00 | ||
An inhibitor of BMP receptor kinases, LDN-193189 indirectly modulates CRIM1 activation by regulating BMP signaling pathways. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
By inhibiting TGF-beta signaling, SB431542 indirectly instigates CRIM1 activation through its interaction with BMP-related pathways. | ||||||
GSK-3 Inhibitor XVI | 252917-06-9 | sc-221691 sc-221691A | 5 mg 25 mg | $180.00 $610.00 | 4 | |
CHIR99021 indirectly activates CRIM1 by modulating Wnt signaling, which can cross-talk with BMP pathways. | ||||||
DMH-1 | 1206711-16-1 | sc-361171 sc-361171B sc-361171A sc-361171C | 10 mg 25 mg 50 mg 100 mg | $213.00 $318.00 $632.00 $1047.00 | 2 | |
DMH1, a BMP receptor kinase inhibitor, indirectly triggers CRIM1 activation by modulating BMP signaling pathways. | ||||||
BML-275 | 866405-64-3 | sc-200689 sc-200689A | 5 mg 25 mg | $96.00 $355.00 | 69 | |
This inhibitor of BMP receptor kinases indirectly initiates CRIM1 activation by modulating BMP signaling pathways. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
As an inhibitor of MAPK signaling, SB203580 can indirectly induce CRIM1 activation by modulating BMP-related pathways. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
A PI3K inhibitor, LY294002 indirectly activates CRIM1 by modulating PI3K/Akt signaling, which interacts with BMP pathways. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A indirectly stimulates CRIM1 activation by inhibiting histone deacetylases (HDACs), which can trigger gene expression related to BMP signaling and CRIM1. | ||||||
Heparin | 9005-49-6 | sc-507344 | 25 mg | $119.00 | 1 | |
Heparin interacts with BMP ligands and receptors, indirectly initiating BMP signaling pathways and consequently CRIM1 activation. | ||||||