CRIM1 Antibody (CREX-2): sc-73860

CRIM1 Antibody (CREX-2) is a mouse monoclonal IgG1 antibody that detects CRIM1 protein of human origin by western blotting (WB). Anti-CRIM1 antibody (CREX-2) is available as a non-conjugated format. CRIM1, or cysteine-rich motor neuron 1, is a glycosylated type I transmembrane protein predominantly expressed in pericytes surrounding the arterial vasculature, podocytes, parietal cells, and mesangial cells of the glomerulus, as well as in the developing spinal cord. CRIM1 features six chordin-like cysteine-rich repeats (CRRs) and an N-terminal insulin-like growth factor binding protein-like motif, with CRRs located in the extracellular domain, which can be cleaved and released as a secreted ectodomain from the cell membrane. CRIM1 structure allows for specific interactions with bone morphogenetic proteins (BMPs), particularly BMP4 and BMP7, functioning as an antagonist that modulates BMP signaling pathways. This interaction leads to the tethering of pre-BMP to the cell surface, thereby reducing the production, processing, and secretion of mature BMP, which is essential for various developmental and physiological processes. CRIM1 plays a vital role in capillary formation and maintenance during angiogenesis, highlighting its importance in vascular development and homeostasis.

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CRIM1 Antibody (CREX-2) References:

1. CRIM1, a novel gene encoding a cysteine-rich repeat protein, is developmentally regulated and implicated in vertebrate CNS development and organogenesis.  |  Kolle, G., et al. 2000. Mech Dev. 90: 181-93. PMID: 10642437
2. Characterisation of Crim1 expression in the developing mouse urogenital tract reveals a sexually dimorphic gonadal expression pattern.  |  Georgas, K., et al. 2000. Dev Dyn. 219: 582-7. PMID: 11084657
3. CRIM1 is involved in endothelial cell capillary formation in vitro and is expressed in blood vessels in vivo.  |  Glienke, J., et al. 2002. Mech Dev. 119: 165-75. PMID: 12464430
4. In ovo electroporation of Crim1 in the developing chick spinal cord.  |  Kolle, G., et al. 2003. Dev Dyn. 226: 107-11. PMID: 12508231
5. CRIM1 regulates the rate of processing and delivery of bone morphogenetic proteins to the cell surface.  |  Wilkinson, L., et al. 2003. J Biol Chem. 278: 34181-8. PMID: 12805376
6. Oncogenic mutations cause dramatic, qualitative changes in the transcriptional activity of c-Myb.  |  Liu, F., et al. 2006. Oncogene. 25: 795-805. PMID: 16205643
7. BMP4 activation and secretion are negatively regulated by an intracellular gremlin-BMP4 interaction.  |  Sun, J., et al. 2006. J Biol Chem. 281: 29349-56. PMID: 16880207
8. Crim1KST264/KST264 mice display a disruption of the Crim1 gene resulting in perinatal lethality with defects in multiple organ systems.  |  Pennisi, DJ., et al. 2007. Dev Dyn. 236: 502-11. PMID: 17106887
9. Crim1KST264/KST264 mice implicate Crim1 in the regulation of vascular endothelial growth factor-A activity during glomerular vascular development.  |  Wilkinson, L., et al. 2007. J Am Soc Nephrol. 18: 1697-708. PMID: 17460146

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CRIM1 Antibody (CREX-2) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-CRIM1 Antibody (CREX-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CRIM1 Antibody (CREX-2) Specifications

Alternate Product Name: CRIM1

Product Clone Name: CREX-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: CRIM1

Epitope Species: human

Product Reactivity/Detection: CRIM1, also designated cysteine-rich motor neuron 1,

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and protein stabilizer

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for CRIM1 Antibody (CREX-2): N/A