CPSF4 Inhibitors
CPSF4 inhibitors belong to a distinctive chemical class that targets a crucial cellular machinery involved in eukaryotic gene expression. CPSF4, or Cleavage and Polyadenylation Specificity Factor 4, is a key component of the pre-mRNA 3' end processing complex, which is responsible for the cleavage and polyadenylation of nascent mRNA transcripts. This process is fundamental for the maturation of mRNA molecules and subsequently influences gene expression at the post-transcriptional level. CPSF4 inhibitors operate by disrupting the normal functioning of CPSF4, leading to the inhibition of proper mRNA processing. The intricate interplay between CPSF4 and its associated factors ensures the accurate formation of the polyadenylated tail, a crucial step for mRNA stability and export from the nucleus to the cytoplasm. Inhibitors targeting CPSF4 thus impede this essential molecular mechanism, thereby influencing the fate of mRNA transcripts and potentially impacting various cellular processes dependent on precise gene regulation.
The development and study of CPSF4 inhibitors have provided valuable insights into the intricate regulatory networks governing gene expression. By selectively modulating CPSF4 activity, researchers aim to unravel the specific consequences on mRNA processing and downstream cellular events. Understanding the intricate details of CPSF4 inhibition could shed light on novel avenues for manipulating gene expression for research purposes or potentially devising strategies for influencing cellular behavior.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Leptomycin B | 87081-35-4 | sc-358688 sc-358688A sc-358688B | 50 µg 500 µg 2.5 mg | $107.00 $416.00 $1248.00 | 35 | |
Inhibits exportin 1 (CRM1), leading to altered mRNA transport and potentially affecting CPSF4-mediated mRNA processing. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $259.00 | 41 | |
Inhibits CDK9, part of the positive transcription elongation factor b (P-TEFb), which is required for transcription elongation that CPSF4 would process. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
Disrupts BET bromodomain proteins, altering transcription regulation and indirectly influencing CPSF4 activity. | ||||||
Pladienolide B | 445493-23-2 | sc-391691 sc-391691B sc-391691A sc-391691C sc-391691D sc-391691E | 0.5 mg 10 mg 20 mg 50 mg 100 mg 5 mg | $299.00 $5699.00 $11099.00 $25500.00 $66300.00 $2875.00 | 63 | |
Binds to the SF3b complex and disrupts splicing, potentially affecting the pool of pre-mRNAs that CPSF4 acts upon. | ||||||
Ispinesib | 336113-53-2 | sc-364747 | 10 mg | $505.00 | ||
Inhibits kinesin spindle protein (KSP), leading to cell cycle arrest, which can indirectly reduce CPSF4 activity due to decreased cellular demand for mRNA processing. | ||||||
Silvestrol | 697235-38-4 | sc-507504 | 1 mg | $920.00 | ||
Inhibits eIF4A, an RNA helicase involved in the initiation of translation, potentially decreasing the demand for CPSF4-mediated mRNA maturation. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Inhibits the 26S proteasome, leading to altered protein turnover and potentially affecting CPSF4 function due to changes in cellular regulatory mechanisms. | ||||||
Rocaglamide | 84573-16-0 | sc-203241 sc-203241A sc-203241B sc-203241C sc-203241D | 100 µg 1 mg 5 mg 10 mg 25 mg | $275.00 $474.00 $1639.00 $2497.00 $5344.00 | 4 | |
Inhibits eIF4A, leading to altered translation initiation and potentially reducing the demand on CPSF4 for mRNA processing. | ||||||