CPSF3 Activators
CPSF3 activators, belonging to a specialized chemical class, are molecules designed to modulate the function of the Cleavage and Polyadenylation Specificity Factor 3 (CPSF3). CPSF3 is a critical component of the pre-mRNA 3' end processing machinery in eukaryotic cells, playing a pivotal role in the maturation of messenger RNA (mRNA). Its primary function is to recognize and cleave the pre-mRNA at the polyadenylation site, a crucial step in mRNA processing that allows for the addition of a polyadenine (poly-A) tail. This poly-A tail is essential for stabilizing the mRNA and promoting its efficient translation and transport out of the nucleus.
CPSF3 activators, through their specific interactions with CPSF3, are capable of fine-tuning the polyadenylation process. They can enhance or modulate CPSF3's enzymatic activity, influencing the efficiency and specificity of mRNA cleavage and polyadenylation. By doing so, these activators impact gene expression at the post-transcriptional level, ultimately affecting the type and quantity of proteins produced by a cell. Researchers are keenly interested in understanding how CPSF3 activators can be employed to gain insights into gene regulation, mRNA stability, and the control of various cellular processes that rely on precise mRNA processing. Moreover, studying CPSF3 activators may shed light on the intricate mechanisms underlying gene expression, with potential applications in fields such as molecular biology and basic research.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin forms covalent bonds with DNA, leading to DNA damage and cellular stress. This DNA damage can activate various cellular processes, including the activation of CPSF3 as a response to repair DNA damage and modulate gene expression. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide is a topoisomerase II inhibitor. By interfering with topoisomerase II, it causes DNA strand breaks and triggers DNA damage response pathways. CPSF3 may be activated as part of the cellular response to repair damaged DNA and control gene expression. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Camptothecin inhibits topoisomerase I, resulting in DNA damage in the form of DNA strand breaks. The cellular response to this DNA damage may involve the activation of CPSF3 to regulate mRNA processing and gene expression. | ||||||
Sodium (meta)arsenite | 7784-46-5 | sc-250986 sc-250986A | 100 g 1 kg | $108.00 $780.00 | 3 | |
Sodium arsenite induces oxidative stress within cells. The cellular response to oxidative stress can involve the activation of various signaling pathways, including those that may lead to CPSF3 activation as part of the stress response. | ||||||
Ellipticine | 519-23-3 | sc-200878 sc-200878A | 10 mg 50 mg | $145.00 $569.00 | 4 | |
Ellipticine is a naturally occurring alkaloid known for its DNA intercalating properties. Its interference with DNA structure and function can affect gene expression, potentially leading to CPSF3 activation. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
5-Fluorouracil is an antimetabolite that disrupts DNA and RNA synthesis. Its impact on nucleotide metabolism can lead to changes in gene expression, including potential CPSF3 activation. | ||||||
Paraquat chloride | 1910-42-5 | sc-257968 | 250 mg | $168.00 | 7 | |
Paraquat is a herbicide that induces oxidative stress in cells. The cellular response to oxidative stress may include the activation of CPSF3 as part of stress-induced gene regulation. | ||||||
Cyclophosphamide | 50-18-0 | sc-361165 sc-361165A sc-361165B sc-361165C | 50 mg 100 mg 500 mg 1 g | $90.00 $146.00 $469.00 $791.00 | 18 | |
Cyclophosphamide can cross-link DNA and induce DNA damage. CPSF3 activation may be a response to repair DNA damage and modulate gene expression following treatment. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $176.00 $426.00 | 43 | |
Adriamycin is an anthracycline. It can intercalate into DNA, leading to DNA damage and the activation of cellular repair mechanisms, including potential CPSF3 activation. | ||||||