COX7a1 Activators
COX7a1 Activators are chemical compounds that enhance the functional activity of COX7a1, a protein involved in the electron transport chain in mitochondria. These compounds enhance COX7a1 activity by affecting specific signaling pathways or biological processes that COX7a1 is directly involved in. For instance, Resveratrol and Nicotinamide riboside enhance the activity of Sirtuin 1 (SIRT1), which deacetylates and activates PGC-1α. Activated PGC-1α promotes mitochondrial biogenesis and function, which includes enhancing the functional activity of COX7a1. On the other hand, Metformin, AICAR, Berberine, Salicylate, and Quercetin are activators of 5' AMP-activated protein kinase (AMPK). Activated AMPK phosphorylates and activates PGC-1α, leading to enhanced mitochondrial function and the activity of COX7a1.
Moreover, Zaprinast, a compound that raises cellular cGMP levels, activates protein kinase G (PKG). PKG phosphorylates and activates PGC-1α, which in turn enhances mitochondrial function and biogenesis, including the activity of COX7a1. Oltipraz and Dimethyl fumarate activate nuclear factor erythroid 2–related factor 2 (Nrf2), promoting the transcription of PGC-1α, thereby indirectly enhancing COX7a1 activity. Pioglitazone and Fenofibrate, activators of peroxisome proliferator-activated receptors gamma and alpha (PPARγ and PPARα) respectively, upregulate the expression of PGC-1α, leading to the promotion of mitochondrial biogenesis and function, including the enhancement of COX7a1 activity.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol enhances the activity of Sirtuin 1 (SIRT1), a protein deacetylase that can deacetylate peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α). The deacetylation of PGC-1α leads to its activation, promoting mitochondrial biogenesis and function, including the activity of COX7a1. | ||||||
Metformin-d6, Hydrochloride | 1185166-01-1 | sc-218701 sc-218701A sc-218701B | 1 mg 5 mg 10 mg | $292.00 $822.00 $1540.00 | 1 | |
Metformin activates 5' AMP-activated protein kinase (AMPK), which can phosphorylate PGC-1α, leading to its activation. Activated PGC-1α promotes mitochondrial biogenesis and function, which includes enhancing the functional activity of COX7a1. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AICAR is an AMPK activator. Activated AMPK can phosphorylate and activate PGC-1α, which in turn enhances mitochondrial biogenesis and function, including the activity of COX7a1. | ||||||
Nicotinamide riboside | 1341-23-7 | sc-507345 | 10 mg | $411.00 | ||
Nicotinamide riboside is a precursor of NAD+, which is a co-substrate for SIRT1. Enhanced SIRT1 activity leads to deacetylation and activation of PGC-1α, promoting mitochondrial biogenesis and function, including the activity of COX7a1. | ||||||
Zaprinast (M&B 22948) | 37762-06-4 | sc-201206 sc-201206A | 25 mg 100 mg | $105.00 $250.00 | 8 | |
Zaprinast raises cellular cGMP levels which can activate protein kinase G (PKG). PKG phosphorylates and activates PGC-1α, which enhances mitochondrial function and biogenesis, including the activity of COX7a1. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Berberine activates AMPK, which phosphorylates and activates PGC-1α. Activated PGC-1α promotes mitochondrial biogenesis and function, leading to the enhancement of COX7a1 activity. | ||||||
Salicylic acid | 69-72-7 | sc-203374 sc-203374A sc-203374B | 100 g 500 g 1 kg | $47.00 $94.00 $119.00 | 3 | |
Salicylate activates AMPK, which phosphorylates and activates PGC-1α. The activated PGC-1α promotes mitochondrial biogenesis and function, enhancing COX7a1 activity. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is an AMPK activator. Activated AMPK can phosphorylate and activate PGC-1α, which enhances mitochondrial function and biogenesis, including the activity of COX7a1. | ||||||
Oltipraz | 64224-21-1 | sc-205777 sc-205777A | 500 mg 1 g | $286.00 $622.00 | ||
Oltipraz activates nuclear factor erythroid 2–related factor 2 (Nrf2), which can promote the transcription of PGC-1α. Increased PGC-1α enhances mitochondrial function and biogenesis, leading to enhanced activity of COX7a1. | ||||||
Pioglitazone hydrochloride | 112529-15-4 | sc-204848 sc-204848A | 100 mg 500 mg | $63.00 $213.00 | 19 | |
Pioglitazone activates peroxisome proliferator-activated receptor gamma (PPARγ), which can upregulate the expression of PGC-1α. Increased PGC-1α promotes mitochondrial function and biogenesis, including the activity of COX7a1. | ||||||