COX6a2 Inhibitors
Antimycin A, Rotenone, and Oligomycin act on different complexes of the electron transport chain but ultimately reduce the efficiency of electron transfer to the COX complex. Compounds such as Cyanide, Azide, Carbon monoxide, Hydrogen sulfide, and Sodium azide directly target the COX complex, specifically the cytochrome c oxidase activity, thereby impeding the function of COX6a2. Their inhibition is due to their high affinity for the heme iron within the enzyme, which is essential for its catalytic activity. By obstructing the terminal step in the electron transport chain, these inhibitors significantly impact cellular respiration.
Zinc and Penicillamine interact with the metal centers that are critical for the structural integrity and function of enzyme complexes, including the COX complex. Zinc's inhibitory effects arise from its potential to displace necessary metal ions, while copper chelators sequester copper, depriving COX6a2 of its requisite cofactor. Allopurinol's role in diminishing reactive oxygen species indirectly affects the COX complex by altering the oxidative environment in which it operates. Diphenyleneiodonium chloride, by inhibiting flavoproteins, reduces the availability of electrons for the cytochrome c oxidase complex, hence affecting COX6a2 activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Antimycin A | 1397-94-0 | sc-202467 sc-202467A sc-202467B sc-202467C | 5 mg 10 mg 1 g 3 g | $55.00 $63.00 $1675.00 $4692.00 | 51 | |
Binds to and inhibits complex III of the electron transport chain, which can reduce electron flow to COX complexes, including COX6a2. | ||||||
Sodium azide | 26628-22-8 | sc-208393 sc-208393B sc-208393C sc-208393D sc-208393A | 25 g 250 g 1 kg 2.5 kg 100 g | $43.00 $155.00 $393.00 $862.00 $90.00 | 8 | |
Inhibits cytochrome c oxidase by binding to the heme group, which can interfere with COX6a2 activity. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $259.00 | 41 | |
Inhibits complex I of the electron transport chain, which can reduce the electron supply to downstream complexes including COX6a2. | ||||||
Oligomycin | 1404-19-9 | sc-203342 sc-203342C | 10 mg 1 g | $149.00 $12495.00 | 18 | |
Inhibits ATP synthase, leading to a feedback inhibition of the electron transport chain that can decrease COX6a2 activity. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Can bind to and inhibit various mitochondrial enzymes, potentially decreasing the activity of COX6a2. | ||||||
Penicillamine | 52-67-5 | sc-205795 sc-205795A | 1 g 5 g | $46.00 $96.00 | ||
Chelate copper, an essential cofactor for COX6a2, which can reduce its activity. | ||||||
Allopurinol | 315-30-0 | sc-207272 | 25 g | $131.00 | ||
Inhibits xanthine oxidase, which can reduce reactive oxygen species production and indirectly affect COX6a2 function. | ||||||
Diphenyleneiodonium chloride | 4673-26-1 | sc-202584E sc-202584 sc-202584D sc-202584A sc-202584B sc-202584C | 10 mg 25 mg 50 mg 100 mg 250 mg 500 mg | $151.00 $136.00 $317.00 $405.00 $944.00 $1837.00 | 24 | |
Inhibits flavoproteins, which can decrease electron flow to the cytochrome c oxidase complex and thus COX6a2 activity. | ||||||