COX17 Activators
The activity of COX17, a copper chaperone critical for the assembly and function of cytochrome c oxidase in mitochondrial respiration, is closely tied to the bioavailability and proper handling of copper within the cell. Compounds such as Copper (II) sulfate, by providing an essential source of copper ions, can indirectly enhance the functional role of COX17 in delivering copper to cytochrome c oxidase. Disulfiram and Clioquinol, known for their copper-binding properties, along with Tetrathiomolybdate used in conditions of copper overload, highlight the importance of copper homeostasis in influencing COX17 activity. These compounds, by modulating the availability and cellular handling of copper, indirectly affect the efficacy with which COX17 can fulfill its role as a chaperone. Similarly, Histidine and Zinc sulfate, through their competitive or binding interactions with copper, might alter the metal's bioavailability, thereby influencing the functional landscape in which COX17 operates.
Furthermore, the broader effects of dietary and pharmacological compounds on mitochondrial function and metal ion homeostasis also play a significant role in modulating COX17 activity. Nutraceuticals like Curcumin, Resveratrol, and Quercetin, known for their effects on metal ion chelation and modulation of cellular pathways, might indirectly affect the environment and efficiency of COX17's chaperoning activity. Vitamin C, with its ability to reduce copper ions, can influence the bioavailability and toxicity of copper, thus indirectly impacting COX17 function. Similarly, antioxidants like Alpha-lipoic acid and N-acetylcysteine, by affecting mitochondrial function and metal ion homeostasis, offer potential routes through which COX17 activity may be influenced. These compounds, through their indirect actions on copper bioavailability, cellular antioxidant status, and mitochondrial health, underscore the complex network of interactions that regulate COX17 function. Collectively, they highlight the intricate balance of copper handling and mitochondrial function critical for the efficient operation of COX17 and its pivotal role in cellular energy production, providing insights into potential strategies for modulating this essential process.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Copper(II) sulfate | 7758-98-7 | sc-211133 sc-211133A sc-211133B | 100 g 500 g 1 kg | $45.00 $120.00 $185.00 | 3 | |
Copper (II) sulfate can provide a source of copper ions, which are necessary for COX17 to function as a chaperone. By increasing the bioavailability of copper, this compound might indirectly enhance the efficacy of COX17 in delivering copper to cytochrome c oxidase. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Disulfiram is a drug known to bind to copper and form a complex. While its primary use is for alcohol dependence, its copper-binding ability suggests it might influence the bioavailability and cellular handling of copper, thereby potentially affecting COX17 function indirectly. | ||||||
Sodium metavanadate | 13718-26-8 | sc-251034 sc-251034A | 5 g 25 g | $31.00 $82.00 | 3 | |
Tetrathiomolybdate is an agent used to treat copper overload disorders like Wilson's disease. It works by forming a tripartite complex with copper and protein, reducing copper levels in the body. While its primary use is for copper reduction, understanding its mechanism can provide insights into how altering copper homeostasis might influence COX17 function indirectly. | ||||||
L-Histidine | 71-00-1 | sc-394101 sc-394101A sc-394101B sc-394101C sc-394101D | 25 g 100 g 250 g 500 g 1 kg | $53.00 $82.00 $185.00 $200.00 $332.00 | 1 | |
Histidine is an amino acid that can bind copper ions, affecting their bioavailability. As copper is a crucial element for COX17 function, histidine supplementation might influence the availability of copper for COX17 and thus indirectly affect its function. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc competes with copper for absorption and cellular transport. Zinc sulfate supplementation might indirectly influence COX17 function by altering copper bioavailability and homeostasis within the cell. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin has been shown to have a variety of biological effects, including the modulation of metal ion homeostasis. While not directly influencing COX17, curcumin might affect copper bioavailability or cellular responses to copper, potentially influencing COX17 function indirectly. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol is known for its beneficial effects on health and longevity, including the modulation of various metal ions. It might indirectly affect COX17 function by altering the cellular handling of copper or by affecting mitochondrial function more broadly, thereby influencing the environment in which COX17 operates. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin is a flavonoid with multiple biological effects, including the chelation of metal ions. By affecting copper bioavailability or cellular handling, quercetin might indirectly influence COX17 function. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $45.00 | 5 | |
Vitamin C can reduce copper ions and affect their bioavailability and toxicity. As such, it might indirectly influence the function of COX17 by affecting the copper ions that are central to COX17's role as a chaperone. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $68.00 $120.00 $208.00 $373.00 $702.00 | 3 | |
An antioxidant that can chelate various metal ions and is involved in mitochondrial bioenergetics. It might indirectly affect COX17's ability to deliver copper to cytochrome c oxidase by influencing mitochondrial function and metal ion homeostasis. | ||||||