COX17 Antibody (A-8): sc-393617
- COX17 Antibody (A-8) is a mouse monoclonal IgG1 κ COX17 antibody, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 1-63 representing full length COX17 of human origin
- COX17 Antibody (A-8) is recommended for detection of COX17 of human origin by WB, IP, IF and ELISA
- Anti-COX17 Antibody (A-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for COX17 Antibody (A-8) for WB applications. These reagents are now offered in bundles with COX17 Antibody (A-8) (see ordering information below).
COX17 Antibody (A-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects COX17 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). COX17 (A-8) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The cytochrome c oxidase (COX) family plays a crucial role in cellular respiration, serving as the final electron donor in the respiratory chain to establish a proton gradient across the inner mitochondrial membrane, which is essential for ATP production. COX17, a nuclear gene product, encodes a mitochondrial copper chaperone protein that is vital for the proper assembly and function of the COX apoenzyme, which is a dimer composed of 13 subunits derived from both mitochondrial and nuclear origins. The importance of COX17 lies in its role in facilitating the transport and incorporation of copper ions into the COX apoenzyme, a process critical for maintaining efficient mitochondrial respiration and overall cellular energy metabolism.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
COX17 Antibody (A-8) References:
- Characterization and localization of human COX17, a gene involved in mitochondrial copper transport. | Punter, FA., et al. 2000. Hum Genet. 107: 69-74. PMID: 10982038
- Characterization of human SCO1 and COX17 genes in mitochondrial cytochrome-c-oxidase deficiency. | Horvath, R., et al. 2000. Biochem Biophys Res Commun. 276: 530-3. PMID: 11027508
- Identification of COX17 as a therapeutic target for non-small cell lung cancer. | Suzuki, C., et al. 2003. Cancer Res. 63: 7038-41. PMID: 14612491
- Cox17 is functional when tethered to the mitochondrial inner membrane. | Maxfield, AB., et al. 2004. J Biol Chem. 279: 5072-80. PMID: 14615477
- Metal-binding mechanism of Cox17, a copper chaperone for cytochrome c oxidase. | Palumaa, P., et al. 2004. Biochem J. 382: 307-14. PMID: 15142040
- Cox17, a copper chaperone for cytochrome c oxidase: expression, purification, and formation of mixed disulphide adducts with thiol reagents. | Voronova, A., et al. 2007. Protein Expr Purif. 53: 138-44. PMID: 17208454
- Oxidative switches in functioning of mammalian copper chaperone Cox17. | Voronova, A., et al. 2007. Biochem J. 408: 139-48. PMID: 17672825
- A structural-dynamical characterization of human Cox17. | Banci, L., et al. 2008. J Biol Chem. 283: 7912-20. PMID: 18093982
- Isolation of a cDNA encoding the human homolog of COX17, a yeast gene essential for mitochondrial copper recruitment. | Amaravadi, R., et al. 1997. Hum Genet. 99: 329-33. PMID: 9050918
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
COX17 Antibody (A-8) | sc-393617 | 200 µg/ml | $322.00 | |||
COX17 Antibody (A-8): m-IgG Fc BP-HRP Bundle | sc-530521 | 200 µg Ab; 10 µg BP | $361.00 | |||
COX17 Antibody (A-8): m-IgGκ BP-HRP Bundle | sc-524026 | 200 µg Ab, 40 µg BP | $361.00 | |||
COX17 Antibody (A-8): m-IgG1 BP-HRP Bundle | sc-544104 | 200 µg Ab; 20 µg BP | $361.00 | |||
COX17 Antibody (A-8) AC | sc-393617 AC | 500 µg/ml, 25% agarose | $424.00 | |||
COX17 Antibody (A-8) HRP | sc-393617 HRP | 200 µg/ml | $322.00 | |||
COX17 Antibody (A-8) FITC | sc-393617 FITC | 200 µg/ml | $336.00 | |||
COX17 Antibody (A-8) PE | sc-393617 PE | 200 µg/ml | $349.00 | |||
COX17 Antibody (A-8) Alexa Fluor® 488 | sc-393617 AF488 | 200 µg/ml | $364.00 | |||
COX17 Antibody (A-8) Alexa Fluor® 546 | sc-393617 AF546 | 200 µg/ml | $364.00 | |||
COX17 Antibody (A-8) Alexa Fluor® 594 | sc-393617 AF594 | 200 µg/ml | $364.00 | |||
COX17 Antibody (A-8) Alexa Fluor® 647 | sc-393617 AF647 | 200 µg/ml | $364.00 | |||
COX17 Antibody (A-8) Alexa Fluor® 680 | sc-393617 AF680 | 200 µg/ml | $364.00 | |||
COX17 Antibody (A-8) Alexa Fluor® 790 | sc-393617 AF790 | 200 µg/ml | $364.00 |