COQ10A Activators
Coenzyme Q10 is a lipid-soluble molecule found in the membranes of many organelles, most notably in the mitochondria. It is a component of the electron transport chain and participates in aerobic cellular respiration, generating energy in the form of ATP. CoQ10 is also recognized for its function as an antioxidant, protecting cells from oxidative damage.
The biosynthesis of CoQ10 is a complex process that involves multiple enzymes, which are encoded by the COQ genes. These enzymes work sequentially to produce CoQ10 from the amino acid tyrosine or phenylalanine through a multi-step pathway. The process includes the formation of the benzoquinone structure and the isoprenoid side chain, with several modification steps along the way.Proteins such as COQ1 through COQ9 have been identified as being involved in the CoQ10 biosynthetic pathway. They are responsible for various steps, such as the prenylation of the quinone ring, hydroxylation, decarboxylation, and methylation reactions that lead to the final product.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $120.00 $326.00 $634.00 $947.00 $1259.00 | 38 | |
These agonists may enhance the expression of genes involved in mitochondrial function and CoQ10 biosynthesis. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Sirtuins influence mitochondrial biogenesis, potentially upregulating CoQ10 biosynthetic enzymes. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Activation of Nrf2 can induce the expression of antioxidant response genes, possibly including those for CoQ10 synthesis. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Inhibition of mTOR may activate compensatory mechanisms that enhance mitochondrial function and CoQ10 production. | ||||||
Simvastatin | 79902-63-9 | sc-200829 sc-200829A sc-200829B sc-200829C | 50 mg 250 mg 1 g 5 g | $31.00 $89.00 $135.00 $443.00 | 13 | |
While statins reduce cholesterol synthesis, they might indirectly upregulate CoQ10 synthesis due to feedback mechanisms. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid regulates gene expression and may affect the expression of enzymes in the CoQ10 pathway. | ||||||
Clofibrate | 637-07-0 | sc-200721 | 1 g | $33.00 | ||
These compounds can induce peroxisomal proliferation, potentially affecting lipid metabolism and CoQ10 synthesis. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Glucocorticoids can modulate mitochondrial function and may influence CoQ10 enzyme expression. | ||||||
L-3,3′,5-Triiodothyronine, free acid | 6893-02-3 | sc-204035 sc-204035A sc-204035B | 10 mg 100 mg 250 mg | $41.00 $77.00 $153.00 | ||
Thyroid hormones upregulate mitochondrial activity, which could include CoQ10 biosynthesis. | ||||||
(+)-α-Tocopherol | 59-02-9 | sc-214454 sc-214454A sc-214454B sc-214454C | 10 g 25 g 100 g 1 kg | $43.00 $62.00 $141.00 $430.00 | ||
Antioxidants may upregulate the expression of endogenous antioxidant systems including CoQ10 synthesis. | ||||||