connexin 50 Activators
Connexin 50 activators are a diverse set of chemical compounds that enhance the functional activity of connexin 50, predominantly through the modulation of gap junction communication. Compounds such as quinine, mefloquine, and halothane directly increase the conductance of connexin 50 channels, thereby facilitating better intercellular communication. Retinoic acid plays a role in cell differentiation and can upregulate the assembly of connexin 50-containing gap junctions. Glycyrrhetinic acid and its derivative carbenoxolone have been noted to interact with gap junction channels to enhance connexin 50 activity, while flufenamic acid increases channel open probability and conductance. Genistein, by inhibiting tyrosine kinase activity, can indirectly increase the activity of connexin 50 by reducing competitive phosphorylation, which is crucial for the proper functioning of gap junctions.
Dibutyryl cAMP and forskolin, through the elevation of intracellular cAMP levels, enhance connexin 50 activity by promoting phosphorylation events that favor gap junction assembly and channel opening. Heptanol, at lower concentrations, reversibly modulates gap junction communication, enhancing connexin 50 function. Lastly, long-chain alcohols like octanol are thought to stabilize gap junctions by interacting with the lipid domains of the cell membrane, indirectly promoting connexin 50-mediated cell-cell communication.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Quinine | 130-95-0 | sc-212616 sc-212616A sc-212616B sc-212616C sc-212616D | 1 g 5 g 10 g 25 g 50 g | $79.00 $104.00 $166.00 $354.00 $572.00 | 1 | |
Quinine specifically targets gap junction communication by enhancing the conductance of connexin 50 gap junction channels, thereby facilitating intercellular communication. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid influences the differentiation of cells in the lens of the eye where connexin 50 is prominent, increasing the intercellular communication by enhancing gap junction assembly. | ||||||
18 β-Glycyrrhetinic Acid | 471-53-4 | sc-205573B sc-205573 sc-205573A sc-205573C sc-205573D | 1 g 5 g 10 g 25 g 100 g | $29.00 $55.00 $87.00 $132.00 $319.00 | 3 | |
18 β-Glycyrrhetinic Acid (Glycyrrhetinic acid) interacts with gap junction channels and has been observed to increase connexin 50 channel activity, thereby enhancing cell-cell communication. | ||||||
1-Heptanol | 111-70-6 | sc-237561 | 100 ml | $113.00 | ||
1-Heptanol is known to reversibly modulate gap junction connectivity; at low concentrations, it can enhance connexin 50 channel function and intercellular communication. | ||||||
Carbenoxolone | 5697-56-3 | sc-507294 | 1 g | $50.00 | ||
Carbenoxolone, a derivative of glycyrrhetinic acid, has been shown to increase the functional activity of connexin 50 by facilitating gap junction communication. | ||||||
Flufenamic acid | 530-78-9 | sc-205699 sc-205699A sc-205699B sc-205699C | 10 g 50 g 100 g 250 g | $27.00 $79.00 $154.00 $309.00 | 1 | |
Flufenamic acid affects gap junction communication and can enhance the activity of connexin 50 by increasing channel open probability and conductance. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that indirectly enhances connexin 50 activity by modulating phosphorylation states, which are critical for gap junction function. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl cAMP elevates intracellular cAMP levels, which can enhance connexin 50 gap junction assembly and channel function through PKA-mediated pathways. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, raising cAMP levels in cells, which in turn enhances connexin 50 gap junction communication by promoting channel opening. | ||||||