Molecular structure of 18 β-Glycyrrhetinic Acid, CAS Number: 471-53-4
18 β-Glycyrrhetinic Acid (CAS 471-53-4)
See product citations (3)
Alternate Names:
3β-Hydroxy-11-oxo-18β,20β-olean-12-en-29-oic acid; Enoxolone
Application:
18 β-Glycyrrhetinic Acid is the aglycone of the triterpenoid Glyccyrrhizic acid
CAS Number:
471-53-4
Purity:
≥98%
Molecular Weight:
470.68
Molecular Formula:
C30H46O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
18 β-Glycyrrhetinic Acid is an aglycone of the triterpenoid Glyccyrrhizic acid, which is found in liquorice. inhibits the PGDH (15-hydroxyprostaglandin dehydrogenase) leading to increased prostaglandin concentration in the digestive system. Also investigated for potential antibiotic activities. 18 β-Glycyrrhetinic Acid is an inhibitor of DinB, DNA pol alpha, DNA pol gamma and DNA pol lambda.
18 β-Glycyrrhetinic Acid (CAS 471-53-4) References
- Antihyperglycemic effect of 18 beta-glycyrrhetinic acid, aglycone of glycyrrhizin, on streptozotocin-diabetic rats. | Kalaiarasi, P. and Pugalendi, KV. 2009. Eur J Pharmacol. 606: 269-73. PMID: 19374864
- 18β-glycyrrhetinic acid induces UDP-glucuronosyltransferase in rats. | Lee, KW. and Ho, WS. 2013. Protein Pept Lett. 20: 1360-4. PMID: 24261979
- Structural basis for 18-β-glycyrrhetinic acid as a novel non-GSH analog glyoxalase I inhibitor. | Zhang, H., et al. 2015. Acta Pharmacol Sin. 36: 1145-50. PMID: 26279158
- 18β-Glycyrrhetinic acid protects against alpha-naphthylisothiocyanate-induced cholestasis through activation of the Sirt1/FXR signaling pathway. | Wu, SY., et al. 2018. Acta Pharmacol Sin. 39: 1865-1873. PMID: 30061734
- Grafting of 18β-Glycyrrhetinic Acid and Sialic Acid onto Chitosan to Produce a New Amphipathic Chitosan Derivative: Synthesis, Characterization, and Cytotoxicity. | Quan, WY., et al. 2021. Molecules. 26: PMID: 33467083
- Prevention of D-GalN/LPS-induced ALI by 18β-glycyrrhetinic acid through PXR-mediated inhibition of autophagy degradation. | Wu, S., et al. 2021. Cell Death Dis. 12: 480. PMID: 33986260
- Peptide conjugates of 18β-glycyrrhetinic acid as potent inhibitors of α-glucosidase and AGEs-induced oxidation. | Khan, SN., et al. 2022. Eur J Pharm Sci. 168: 106045. PMID: 34666184
- A Review on Structure-Activity Relationships of Glycyrrhetinic Acid Derivatives with Diverse Bioactivities. | Liu, Y., et al. 2022. Mini Rev Med Chem. 22: 2024-2066. PMID: 35081889
- New 18β-Glycyrrhetinic Acid-Emodin Esters Synthetized by a One-Step Innovative Route, Its Structural Characterization, and in Vivo Toxicity Assessed on Zebrafish Models. | Zhong, Y., et al. 2022. Chem Biodivers. 19: e202100928. PMID: 35243763
- Novel 18β-glycyrrhetinic acid derivatives as a Two-in-One agent with potent antimicrobial and anti-inflammatory activity. | Tu, B., et al. 2022. Bioorg Chem. 122: 105714. PMID: 35276603
- In vitro growth inhibitory effect of selected 18β-glycyrrhetinic acid esters on Theileriaannulata. | Buvanesvaragurunathan, K., et al. 2022. Exp Parasitol. 236-237: 108258. PMID: 35421387
- 18β-Glycyrrhetinic acid altered the intestinal permeability in the human Caco-2 monolayer cell model. | Malekinejad, M., et al. 2022. Eur J Nutr. 61: 3437-3447. PMID: 35578042
- 18β-Glycyrrhetinic acid ameliorates endoplasmic reticulum stress-induced inflammation in pulmonary arterial hypertension through PERK/eIF2α/NF-κB signaling. | Wang, JL., et al. 2022. Chin J Physiol. 65: 187-198. PMID: 36073567
- 18β-glycyrrhetinic Acid Modulated Autophagy is Cytotoxic to Breast Cancer Cells. | Hsu, YC., et al. 2023. Int J Med Sci. 20: 444-454. PMID: 37057216
- Chemopreventive drug development: perspectives and progress. | Kelloff, GJ., et al. 1994. Cancer Epidemiol Biomarkers Prev. 3: 85-98. PMID: 8118391
Inhibitor of:
β-Glucoronidase, 11β-HSD2, AKR1C14, connexin 23, connexin 25, connexin 26, connexin 30, connexin 36, connexin 39, connexin 40.1, connexin 46, connexin 47, connexin 59, DinB, DNA pol γ, DNA pol alpha, DNA pol lambda, FXRβ, INSIG-1, PGDH, TMEM16K, and TMEM202.Activator of:
AKR1C19, connexin 30.3, connexin 39, connexin 46, connexin 50, and Progesterone.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
18 β-Glycyrrhetinic Acid, 1 g | sc-205573B | 1 g | $28.00 | |||
18 β-Glycyrrhetinic Acid, 5 g | sc-205573 | 5 g | $54.00 | |||
18 β-Glycyrrhetinic Acid, 10 g | sc-205573A | 10 g | $85.00 | |||
18 β-Glycyrrhetinic Acid, 25 g | sc-205573C | 25 g | $129.00 | |||
18 β-Glycyrrhetinic Acid, 100 g | sc-205573D | 100 g | $313.00 |