connexin 36 Inhibitors
The chemical class of Connexin 36 Inhibitors includes a variety of compounds that can potentially inhibit the function of Connexin 36 indirectly by targeting cellular processes and signaling pathways related to gap junction formation and neuronal communication. Carbenoxolone and 18α-Glycyrrhetinic Acid are known gap junction blockers that can disrupt intercellular communication, thereby potentially inhibiting Cx36-mediated gap junctions in neurons. Similarly, 2-APB, through its modulation of intracellular Ca²⁺ signaling, can influence the function of Cx36 in forming gap junctions.
Nonsteroidal anti-inflammatory drugs like Meclofenamic Acid and Flufenamic Acid, by disrupting gap junction communication, could indirectly inhibit Cx36. Quinine and Lidocaine, known for their effects on ion channels, might indirectly affect Cx36 function by altering neuronal excitability and signaling. Anesthetics such as Halothane, by modulating neuronal activity, can potentially disrupt neuronal gap junctions involving Cx36. Tetrodotoxin, as a sodium channel blocker, could similarly influence neuronal activity and thus Cx36 function. Octanol and Heptanol, both known to block gap junctional communication, represent a direct approach to inhibiting gap junctions, including those formed by Cx36. Baicalein, with its broad effects on signaling pathways, could potentially impact the expression or function of Cx36 in neurons.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Carbenoxolone disodium | 7421-40-1 | sc-203868 sc-203868A sc-203868B sc-203868C | 1 g 5 g 10 g 25 g | $45.00 $197.00 $351.00 $759.00 | 1 | |
A gap junction blocker that can indirectly inhibit Cx36 by disrupting gap junction communication. | ||||||
18 β-Glycyrrhetinic Acid | 471-53-4 | sc-205573B sc-205573 sc-205573A sc-205573C sc-205573D | 1 g 5 g 10 g 25 g 100 g | $28.00 $54.00 $85.00 $129.00 $313.00 | 3 | |
Inhibits gap junctional communication, potentially affecting Cx36-mediated neuronal coupling. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $27.00 $52.00 | 37 | |
Modulates intracellular Ca²⁺ signaling, potentially influencing Cx36 function in gap junction formation. | ||||||
Meclofenamic Acid | 644-62-2 | sc-211780 | 5 mg | $394.00 | ||
A nonsteroidal anti-inflammatory drug that can disrupt gap junction communication, potentially inhibiting Cx36. | ||||||
Quinine | 130-95-0 | sc-212616 sc-212616A sc-212616B sc-212616C sc-212616D | 1 g 5 g 10 g 25 g 50 g | $77.00 $102.00 $163.00 $347.00 $561.00 | 1 | |
Known to modulate ion channels and could indirectly affect Cx36 function by altering neuronal excitability. | ||||||
Baicalein | 491-67-8 | sc-200494 sc-200494A sc-200494B sc-200494C | 10 mg 100 mg 500 mg 1 g | $31.00 $41.00 $159.00 $286.00 | 12 | |
Modulates various signaling pathways, potentially impacting Cx36 expression or function. | ||||||
1-Octanol | 111-87-5 | sc-255858 | 1 ml | $45.00 | ||
Known to block gap junctional communication, which could indirectly inhibit Cx36. | ||||||
1-Heptanol | 111-70-6 | sc-237561 | 100 ml | $111.00 | ||
Another gap junction blocker, can inhibit gap junction communication including Cx36-mediated connections. | ||||||
Flufenamic acid | 530-78-9 | sc-205699 sc-205699A sc-205699B sc-205699C | 10 g 50 g 100 g 250 g | $26.00 $77.00 $151.00 $303.00 | 1 | |
A nonsteroidal anti-inflammatory drug, similar to meclofenamic acid, can disrupt gap junction communication. | ||||||
Lidocaine | 137-58-6 | sc-204056 sc-204056A | 50 mg 1 g | $50.00 $128.00 | ||
A local anesthetic known to modulate ion channels, potentially affecting Cx36-mediated neuronal communication. | ||||||