connexin 36 Antibody (H-9): sc-398063

connexin 36 Antibody (H-9) is a mouse monoclonal IgG2a kappa light chain antibody that detects connexin 36 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-connexin 36 antibody (H-9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. connexin 36 plays a crucial role in forming gap junctions, specialized intercellular connections that allow direct transfer of ions and small molecules between adjacent cells. This function is particularly important in the nervous system, where connexin 36 facilitates electrical coupling between neurons, influencing neuronal excitability and synchrony. connexin 36′s ability to form functional channels is determined by a unique structure, including four transmembrane domains and specific extracellular loops that dictate channel permeability and gating properties. Notably, alterations in connexin 36 expression have been linked to various neurological conditions, highlighting connexin 36′s significance in maintaining proper neuronal communication and function. Using connexin 36 monoclonal antibody (H-9) in research can provide valuable insights into connexin 36′s role in both normal physiology and disease states.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

connexin 36 Antibody (H-9) References:

1. Global ischemia-induced increases in the gap junctional proteins connexin 32 (Cx32) and Cx36 in hippocampus and enhanced vulnerability of Cx32 knock-out mice.  |  Oguro, K., et al. 2001. J Neurosci. 21: 7534-42. PMID: 11567043
2. Emerging issues of connexin channels: biophysics fills the gap.  |  Harris, AL. 2001. Q Rev Biophys. 34: 325-472. PMID: 11838236
3. Expression of connexin36 in cone pedicles and OFF-cone bipolar cells of the mouse retina.  |  Feigenspan, A., et al. 2004. J Neurosci. 24: 3325-34. PMID: 15056712
4. Connexin 36 in photoreceptor cells: studies on transgenic rod-less and cone-less mouse retinas.  |  Dang, L., et al. 2004. Mol Vis. 10: 323-7. PMID: 15152186
5. Association of the connexin36 gene with juvenile myoclonic epilepsy.  |  Mas, C., et al. 2004. J Med Genet. 41: e93. PMID: 15235036
6. Biophysical evidence that connexin-36 forms functional gap junction channels between pancreatic mouse beta-cells.  |  Moreno, AP., et al. 2005. Am J Physiol Endocrinol Metab. 288: E948-56. PMID: 15625088
7. Expression of connexin 36 in central nervous system and its role in epileptic seizure.  |  Peng, YF., et al. 2012. Chin Med J (Engl). 125: 2365-70. PMID: 22882863
8. Connexin 36, a key element in pancreatic beta cell function.  |  Pérez-Armendariz, EM. 2013. Neuropharmacology. 75: 557-66. PMID: 23973309
9. Human cardiac gap junctions: isolation, ultrastructure, and protein composition.  |  Manjunath, CK., et al. 1987. J Mol Cell Cardiol. 19: 131-4. PMID: 3573042
10. Restoring connexin-36 function in diabetogenic environments precludes mouse and human islet dysfunction.  |  St Clair, JR., et al. 2023. J Physiol. 601: 4053-4072. PMID: 37578890
11. Connexin 36 Mediated Intercellular Endoplasmic Reticulum Stress Transmission Induces SSTA Resistance in Growth Hormone Pituitary Adenoma.  |  Wang, Z., et al. 2024. Int J Biol Sci. 20: 801-817. PMID: 38169563
12. Decreased connexin expression and intercellular communication in human bladder cancer cells.  |  Grossman, HB., et al. 1994. Cancer Res. 54: 3062-5. PMID: 8187096

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-connexin 36 Antibody (H-9) has 7 citations in a variety of scientific publications.

Primary antibodies like Anti-connexin 36 Antibody (H-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

connexin 36 Antibody (H-9) Specifications

Alternate Product Name: GJD2

Product Clone Name: H-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 286-321

Epitope Target: connexin 36

Epitope Species: human

Product Reactivity/Detection: connexin 36

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine, bovine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 7 citations in various scientific publications

Available Conjugates/Forms for connexin 36 Antibody (H-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin