COMMD4 Activators
COMMD4 activators belong to a category of chemical compounds that interact specifically with the COMMD family member 4, a protein that is part of a larger group of proteins known as the COMMD (Copper Metabolism Murr1 Domain-containing) family. This family is involved in various cellular processes such as copper homeostasis, sodium transport, and the degradation of certain proteins. The precise function of COMMD4 is not as well-characterized as some of the other members of the COMMD family, but it is understood to play a role in the regulation of gene expression and may be involved in cellular responses to oxidative stress. The activators of COMMD4 are therefore of interest due to their specific interaction with this protein, which can modulate its activity within the cell.
Activators of COMMD4 are typically small molecules that can bind to the COMMD4 protein and alter its function. By doing so, these compounds can influence the behavior of COMMD4 within various cellular pathways. The mechanism of action for these activators usually involves a direct interaction with the protein, potentially affecting its stability, its ability to form complexes with other proteins, or its subcellular localization. The study of COMMD4 activators is largely focused on understanding how these compounds can modify COMMD4's role within the cell and how this, in turn, affects the cellular processes in which COMMD4 is involved. The biochemical characteristics of these activators, such as their binding affinity and specificity, are key areas of investigation, as they contribute to our understanding of the fundamental interactions between small molecules and their protein targets.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc ions can function as signaling molecules affecting various pathways. Zinc can bind to COMMD4, which may be involved in metal ion homeostasis, leading to its functional activation. | ||||||
Copper(II) sulfate | 7758-98-7 | sc-211133 sc-211133A sc-211133B | 100 g 500 g 1 kg | $46.00 $122.00 $189.00 | 3 | |
Copper ions, like zinc, can act as signaling molecules. Copper has been shown to interact with the COMMD family of proteins, potentially enhancing the activity of COMMD4 through direct binding and stabilization. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin can inhibit NF-κB, a transcription factor that negatively regulates the expression of many proteins including COMMD4. By inhibiting NF-κB, curcumin could lead to the relative increase in functional COMMD4 activity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates SIRT1, which in turn can deacetylate and activate various proteins. SIRT1 activation may thus enhance COMMD4 activity by post-translational modifications. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is known to inhibit NF-κB similarly to curcumin, potentially leading to enhanced COMMD4 activity through a reduction in NF-κB mediated repression. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG inhibits NF-κB and could also affect the activity of COMMD4 through this pathway, reducing NF-κB mediated repression and potentially enhancing COMMD4 activity. | ||||||
β-Nicotinamide mononucleotide | 1094-61-7 | sc-212376 sc-212376A sc-212376B sc-212376C sc-212376D | 25 mg 100 mg 1 g 2 g 5 g | $110.00 $150.00 $220.00 $300.00 $600.00 | 4 | |
NMN is a precursor of NAD+ and can enhance SIRT1 activity. Increased SIRT1 activity may promote deacetylation and activation of COMMD4. | ||||||
Sodium Salicylate | 54-21-7 | sc-3520 sc-3520A sc-3520B sc-3520C | 1 g 25 g 500 g 1 kg | $10.00 $26.00 $82.00 $139.00 | 8 | |
Sodium salicylate can inhibit NF-κB activation. Through this inhibition, it might lead to an increase in COMMD4 activity by lessening NF-κB mediated repression. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone exerts anti-inflammatory effects partly through the inhibition of NF-κB. This glucocorticoid could thus indirectly enhance COMMD4 activity by reducing NF-κB signaling. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane activates NRF2, which can lead to the expression of protective genes and may interact with COMMD family proteins, potentially enhancing COMMD4 activity. | ||||||