COL4A1 Inhibitors
The class of COL4A1 inhibitors comprises a diverse array of chemical compounds that exert their inhibitory effects on the collagen type IV alpha 1 chain (COL4A1). These compounds, selected based on their distinct mechanisms of action, target various cellular pathways and processes to modulate COL4A1 activity, ultimately influencing the maintenance of basement membranes. One notable member of this class is Cilengitide, a cyclic RGD-containing peptide that inhibits integrins, specifically αvβ3 and αvβ5. Another compound, NDGA (Nordihydroguaiaretic Acid), exhibits anti-inflammatory properties and inhibits lipoxygenase enzymes. NDGA's influence on arachidonic acid metabolism may indirectly affect collagen synthesis pathways, influencing COL4A1 activity and basement membrane integrity. SB-3CT, a matrix metalloproteinase (MMP) inhibitor, targets gelatinases MMP-2 and MMP-9.
Ethacrynic Acid, a diuretic, inhibits glutathione S-transferase (GST) activity, affecting cellular detoxification mechanisms. Ethacrynic Acid's impact on detoxification pathways indirectly influences COL4A1 activity and the maintenance of basement membranes. N-Acetylcysteine (NAC), a precursor of glutathione, exhibits antioxidant properties, influencing redox-sensitive pathways related to collagen synthesis. NAC's antioxidant effects contribute to the indirect modulation of COL4A1 activity. Gallotannin, a polyphenolic compound, inhibits collagenase activity, disrupting collagen breakdown. This inhibition of collagenases indirectly influences COL4A1 activity and the preservation of basement membrane structure. PD98059, a selective MEK1 inhibitor, targets the MAPK/ERK pathway, impacting downstream signaling pathways related to collagen synthesis. PD98059's effects on the MAPK/ERK pathway contribute to the indirect modulation of COL4A1 activity Acetylsalicylic Acid (Aspirin), a nonsteroidal anti-inflammatory drug, inhibits cyclooxygenases (COX), influencing inflammation and prostaglandin synthesis. Aspirin's anti-inflammatory effects contribute to the indirect modulation of COL4A1 activity. Y-27632, a selective inhibitor of Rho-associated protein kinase (ROCK), impacts cytoskeletal dynamics and cellular processes related to collagen synthesis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cilengitide | 188968-51-6 | sc-507335 | 5 mg | $215.00 | ||
Cilengitide is a cyclic RGD-containing peptide that inhibits integrins, specifically αvβ3 and αvβ5. Integrins play a role in cell adhesion, migration, and angiogenesis. In the context of COL4A1 inhibition, cilengitide may disrupt cell-matrix interactions and downstream signaling pathways, indirectly modulating COL4A1 activity and its functions related to extracellular matrix maintenance. | ||||||
NDGA (Nordihydroguaiaretic acid) | 500-38-9 | sc-200487 sc-200487A sc-200487B | 1 g 5 g 25 g | $109.00 $384.00 $2190.00 | 3 | |
NDGA is a polyphenolic compound that exhibits anti-inflammatory and antioxidant properties. It can inhibit lipoxygenase enzymes, impacting arachidonic acid metabolism. In the context of COL4A1 inhibition, NDGA's anti-inflammatory effects may influence pathways related to collagen synthesis and deposition, potentially modulating COL4A1 activity and the maintenance of basement membranes. | ||||||
SB-3CT | 292605-14-2 | sc-205847 sc-205847A | 1 mg 5 mg | $102.00 $388.00 | 15 | |
SB-3CT is a matrix metalloproteinase (MMP) inhibitor, specifically targeting gelatinases MMP-2 and MMP-9. MMPs play a role in extracellular matrix remodeling. In the context of COL4A1 inhibition, SB-3CT may prevent MMP-mediated degradation of collagen, indirectly influencing COL4A1 activity and the integrity of basement membranes. | ||||||
Simvastatin | 79902-63-9 | sc-200829 sc-200829A sc-200829B sc-200829C | 50 mg 250 mg 1 g 5 g | $31.00 $89.00 $135.00 $443.00 | 13 | |
Simvastatin is an HMG-CoA reductase inhibitor commonly used to lower cholesterol levels. It may impact the mevalonate pathway, affecting protein prenylation and various cellular processes. In the context of COL4A1 inhibition, simvastatin's modulation of the mevalonate pathway may influence collagen synthesis and deposition, indirectly affecting COL4A1 activity and basement membrane integrity. | ||||||
Ethacrynic acid | 58-54-8 | sc-257424 sc-257424A | 1 g 5 g | $90.00 $300.00 | 5 | |
Ethacrynic acid is a diuretic that can inhibit glutathione S-transferase (GST) activity. GSTs play a role in detoxification processes. In the context of COL4A1 inhibition, ethacrynic acid's inhibition of GSTs may impact cellular detoxification mechanisms, indirectly influencing COL4A1 activity and the maintenance of basement membranes. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $34.00 $74.00 $270.00 $114.00 | 34 | |
N-Acetyl-L-cysteine is a precursor of glutathione and exhibits antioxidant properties. It may impact cellular redox balance. In the context of COL4A1 inhibition, NAC's antioxidant effects may influence redox-sensitive pathways related to collagen synthesis and deposition, indirectly modulating COL4A1 activity and the maintenance of basement membranes. | ||||||
Gallotannin | 1401-55-4 | sc-202619 sc-202619A sc-202619B sc-202619C sc-202619D sc-202619E sc-202619F | 1 g 10 g 100 g 250 g 1 kg 2.5 kg 5 kg | $26.00 $37.00 $67.00 $78.00 $234.00 $536.00 $983.00 | 12 | |
Gallotannin is a polyphenolic compound that can inhibit collagenase activity. Collagenases, including MMPs, play a role in collagen degradation. In the context of COL4A1 inhibition, gallotannin's inhibition of collagenases may prevent collagen breakdown, indirectly influencing COL4A1 activity and the preservation of basement membrane structure. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a selective inhibitor of MEK1, a component of the MAPK/ERK signaling pathway. In the context of COL4A1 inhibition, PD98059's inhibition of the MAPK/ERK pathway may impact downstream signaling pathways related to collagen synthesis and deposition, indirectly modulating COL4A1 activity and the maintenance of basement membranes. | ||||||
Tranilast | 53902-12-8 | sc-200389 sc-200389A sc-200389B sc-200389C | 10 mg 50 mg 1 g 5 g | $31.00 $103.00 $283.00 $978.00 | 2 | |
Tranilast is an anti-allergic drug that exhibits anti-inflammatory and antifibrotic effects. It may impact TGF-β signaling and collagen synthesis. In the context of COL4A1 inhibition, tranilast's effects on TGF-β signaling may influence pathways related to collagen deposition, indirectly modulating COL4A1 activity and basement membrane integrity. | ||||||
Dimethyl fumarate | 624-49-7 | sc-239774 | 25 g | $28.00 | 6 | |
Dimethyl fumarate is an anti-inflammatory and antioxidant compound. It activates the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway. In the context of COL4A1 inhibition, dimethyl fumarate's activation of Nrf2 may impact pathways related to collagen metabolism, indirectly modulating COL4A1 activity and the maintenance of basement membranes. | ||||||