COL4A1 Antibody (5E10): sc-517572

COL4A1 Antibody (5E10) is a mouse monoclonal IgG antibody that detects COL4A1 protein of mouse, rat, and human origin by immunofluorescence (IF) and immunohistochemistry. Anti-COL4A1 antibody (5E10) is available as a non-conjugated format. COL4A1 is a crucial component of type IV collagen, primarily found in basement membranes of various tissues, including kidneys, lungs, and blood vessels. COL4A1 (5E10) monoclonal antibody helps study proper function vital for maintaining structural integrity and filtration properties of these membranes, which play a significant role in tissue homeostasis and organ function. Mutations in COL4A1 can lead to various disorders, including vascular and kidney diseases, highlighting COL4A1′s importance in health and disease. The extensive family of collagen proteins, including COL4A1, features a unique triple helix structure providing tensile strength and stability to the extracellular matrix. This structural feature enables complex connective tissues to withstand mechanical stress while facilitating cell adhesion and communication. Anti-COL4A1 antibody (5E10) serves as an invaluable tool for researchers studying COL4A1′s role in both normal physiology and pathological conditions.

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COL4A1 Antibody (5E10) References:

1. Collagen and bone strength.  |  Boskey, AL., et al. 1999. J Bone Miner Res. 14: 330-5. PMID: 10027897
2. Review article: platelet-collagen interactions: membrane receptors and intracellular signalling pathways.  |  Alberio, L. and Dale, GL. 1999. Eur J Clin Invest. 29: 1066-76. PMID: 10583456
3. Type-IV collagen related diseases.  |  Pescucci, C., et al. 2003. J Nephrol. 16: 314-6. PMID: 12768082
4. Discovery of type IV collagen non-collagenous domains as novel integrin ligands and endogenous inhibitors of angiogenesis.  |  Kalluri, R. 2002. Cold Spring Harb Symp Quant Biol. 67: 255-66. PMID: 12858548
5. Effects of type IV collagen and laminin on the cryopreservation of human embryonic stem cells.  |  Kim, SJ., et al. 2004. Stem Cells. 22: 950-61. PMID: 15536186
6. Cell adhesion to collagenous matrices.  |  McCarthy, JB., et al. 1996. Biopolymers. 40: 371-81. PMID: 8765608
7. Versatile collagens in invertebrates.  |  Engel, J. 1997. Science. 277: 1785-6. PMID: 9324767
8. The cartilage collagens: a review of their structure, organization, and role in the pathogenesis of experimental arthritis in animals and in human rheumatic disease.  |  Cremer, MA., et al. 1998. J Mol Med (Berl). 76: 275-88. PMID: 9535561

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-COL4A1 Antibody (5E10) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-COL4A1 Antibody (5E10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

COL4A1 Antibody (5E10) Specifications

Alternate Product Name: COL4A1

Product Clone Name: 5E10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG

Amino Acids:

Epitope Target: Collagen α1 Type IV

Epitope Species: human

Product Reactivity/Detection: Collagen α1 Type IV

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: IF, IHC(P)

Vialing Information: Each vial contains 100 µg IgG in 1.0 ml of PBS with < 0.1% sodium azide, 0.1% gelatin and 5% glycerol

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for COL4A1 Antibody (5E10): N/A