COBLL1 Activators
COBLL1 activators encompass a diverse array of chemical compounds that indirectly enhance the functional activity of COBLL1 through various signaling pathways. Forskolin, PMA, and db-cAMP, through the elevation of cAMP and activation of PKA and PKC, respectively, play a critical role in modulating downstream pathways that influence COBLL1's role in cytoskeletal reorganization and cell adhesion dynamics. Ionomycin, by increasing intracellular calcium levels, potentially activates calcium-dependent signaling mechanisms, thus affecting COBLL1's involvement in cell morphology and motility. Insulin's action through the PI3K/Akt pathway and EGF through the EGFR pathway both serve to activate complex intracellular cascades that may enhance COBLL1's contribution to glucose metabolism as well as cellular adhesion and migration, respectively. LPA and S1P, by activating their respective G-protein-coupled receptors, likely influence COBLL1 activity by modulating the actin cytoskeleton and cellular motility, critical aspects of COBLL1's functional repertoire.
Moreover, the tuning of cellular phosphorylation states by compounds such as Calyculin A, which inhibits protein phosphatases, could lead to an indirect enhancement of COBLL1's role in signaling pathways associated with actin dynamics. U0126's inhibition of MEK and Y-27632's inhibition of ROCK both contribute to the fine-tuning of signaling pathways that could favor COBLL1's activities in cell adhesion andmigration. Blebbistatin's myosin II inhibition might also indirectly enhance COBLL1's function in cell motility by modulating the actin-myosin contractile framework. Collectively, these activators work synergistically or in parallel to modulate the cellular signaling landscape, providing a conducive environment for the enhancement of COBLL1-mediated processes. These processes primarily include the regulation of cell shape, motility, and the intricate dynamics of the actin cytoskeleton, which are vital for the proper functioning of COBLL1 within cellular contexts.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin increases intracellular cAMP, which in turn activates PKA. PKA phosphorylation can lead to the activation of downstream pathways that COBLL1 is involved in, such as actin cytoskeleton reorganization. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which may enhance COBLL1's role in cell migration and invasion by modulating the cytoskeleton and cellular adhesions. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin raises intracellular calcium levels, which can activate calcium-sensitive signaling pathways potentially influencing COBLL1's function in cell morphology and motility. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Insulin activates the PI3K/Akt pathway, which can indirectly lead to the activation of pathways influencing COBLL1, promoting glucose uptake and glycogen synthesis. | ||||||
Lysophosphatidic Acid | 325465-93-8 | sc-201053 sc-201053A | 5 mg 25 mg | $96.00 $334.00 | 50 | |
LPA activates G-protein coupled receptors, potentially influencing COBLL1 activity by modulating the actin cytoskeleton and cellular motility. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
S1P activates S1P receptors and may enhance COBLL1's function in cell migration and angiogenesis through the Rho/Rac signaling pathways. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Calyculin A is a potent inhibitor of protein phosphatases 1 and 2A, leading to increased phosphorylation levels that could influence COBLL1's role in actin cytoskeleton dynamics. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
db-cAMP is a cAMP analog that activates PKA, potentially enhancing COBLL1's role in signal transduction pathways related to cell morphology and migration. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 selectively inhibits ROCK, potentially enhancing COBLL1's role in actin cytoskeleton organization and cell motility. | ||||||