CNT1 Inhibitors
CNT1 inhibitors, short for Concentrative Nucleoside Transporter 1 inhibitors, are a class of chemical compounds designed to selectively target and modulate the activity of the Concentrative Nucleoside Transporter 1 protein. CNT1 is a transmembrane protein that plays a crucial role in nucleoside transport across cell membranes. It is primarily responsible for the uptake of purine and pyrimidine nucleosides, including essential molecules like adenosine and cytidine, into cells. Inhibition of CNT1 can have profound effects on nucleoside homeostasis within cells and can influence various cellular processes.
CNT1 inhibitors are designed with the aim of regulating nucleoside transport by binding to CNT1 and altering its function. By blocking or reducing the activity of CNT1, these inhibitors can disrupt the normal flow of nucleosides into cells. This, in turn, can impact DNA and RNA synthesis, cell signaling, and energy metabolism. Researchers are particularly interested in CNT1 inhibitors because of their potential to selectively target specific cell types or diseases that rely heavily on nucleoside transport.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
2′-Deoxy-2′,2′-difluorocytidine | 95058-81-4 | sc-275523 sc-275523A | 1 g 5 g | $56.00 $128.00 | ||
This nucleoside analog achieves inhibition of CNT1 by mimicking natural nucleosides, thereby competitively binding to the CNT1 transporter. This competition disrupts the normal uptake of nucleosides by the cells, effectively inhibiting the function of CNT1. | ||||||
S-(4-Nitrobenzyl)-6-thioinosine (NBTI, NBMPR) | 38048-32-7 | sc-200117 | 50 mg | $160.00 | 1 | |
A potent inhibitor of equilibrative nucleoside transporters (ENTs), which can affect nucleoside uptake. | ||||||
Tubercidin | 69-33-0 | sc-258322 sc-258322A sc-258322B | 10 mg 50 mg 250 mg | $184.00 $663.00 $1958.00 | ||
A nucleoside analog that can inhibit adenosine uptake by nucleoside transporters. | ||||||
Vidarabine Monohydrate | 24356-66-9 | sc-296694 | 1 g | $199.00 | ||
Vidarabine Monohydrate inhibits CNT1 through its incorporation into viral DNA, leading to a blockade of the nucleoside transport pathways. This inhibition mechanism primarily disrupts viral replication processes, indirectly affecting CNT1's transport capabilities. | ||||||
2-Chloro-2′-deoxyadenosine | 4291-63-8 | sc-202399 | 10 mg | $144.00 | 1 | |
A nucleoside analog that can be used to probe the function of nucleoside transporters in cells. | ||||||
Penciclovir | 39809-25-1 | sc-203183 | 100 mg | $255.00 | ||
Penciclovir achieves inhibition of CNT1 by mimicking the structure of nucleosides, which allows it to compete with natural nucleosides for uptake by CNT1, thereby inhibiting the normal function of the transporter in nucleoside absorption. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $58.00 $170.00 | 15 | |
While primarily a calcium channel blocker, it also shows inhibitory effects on nucleoside transporters. | ||||||
Reserpine | 50-55-5 | sc-203370 sc-203370A | 1 g 5 g | $134.00 $406.00 | 1 | |
Known for its role in neurotransmitter transport, it can also affect nucleoside transporter function. | ||||||
Cidofovir | 113852-37-2 | sc-482141 | 50 mg | $135.00 | ||
An antiviral drug that relies on nucleoside transporters for cellular entry; its uptake can be affected by transporter inhibitors. | ||||||
3′-Azido-3′-deoxythymidine | 30516-87-1 | sc-203319 | 10 mg | $60.00 | 2 | |
This compound inhibits CNT1 by incorporating into the DNA of viruses, which prevents the normal function of nucleoside transporters like CNT1 by blocking their binding sites, thus hindering the cellular uptake of necessary nucleosides. | ||||||