CMYA5 Activators
CMYA5 Activators are a class of chemical compounds that enhance the functional activity of CMYA5, a protein associated with the cell membrane and known to be involved in calcium signaling and protein kinase pathways. Compounds such as Brefeldin A promote the correct intracellular trafficking of CMYA5, thus facilitating its functional activity. Verapamil, Forskolin, IBMX, Epinephrine, and Isoproterenol enhance CMYA5 activity by triggering the PKA pathway, a signaling cascade that can phosphorylate CMYA5. In particular, Verapamil inhibits calcium channels, leading to PKA pathway activation, while Forskolin and IBMX increase cAMP levels, and Epinephrine and Isoproterenol activate the beta-adrenergic receptor.
Other compounds such as 6-Bnz-cAMP, PMA, Staurosporine, Okadaic Acid, Ionomycin, and Thapsigargin also enhance CMYA5 activity through various mechanisms. Specifically, 6-Bnz-cAMP directly activates PKA, which phosphorylates CMYA5. PMA and Staurosporine are both activators of PKC, another kinase that can phosphorylate CMYA5. Okadaic Acid enhances the phosphorylation state of CMYA5 by inhibiting protein phosphatases PP1 and PP2A. Ionomycin and Thapsigargin enhance CMYA5 activity by increasing intracellular calcium levels, a critical factor considering CMYA5's role as a calcium-binding protein. In particular, Ionomycin acts as a calcium ionophore, while Thapsigargin inhibits SERCA, an ATPase that controls cytoplasmic calcium levels.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Brefeldin A induces protein transport from the endoplasmic reticulum to the Golgi apparatus. CMYA5 is a membrane-associated protein and Brefeldin A can enhance the activity of CMYA5 by promoting its correct intracellular trafficking. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $367.00 | ||
Verapamil inhibits calcium channels, which can lead to the activation of the PKA pathway. Since CMYA5 can be phosphorylated by PKA, Verapamil can enhance the activity of CMYA5 by increasing PKA activity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, leading to an increase in cAMP levels and activation of the PKA pathway. Given that CMYA5 can be phosphorylated by PKA, Forskolin can enhance the activity of CMYA5 by stimulating PKA. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX inhibits phosphodiesterases, leading to an increase in cAMP levels. Since CMYA5 can be phosphorylated by PKA, which is activated by cAMP, IBMX can enhance the activity of CMYA5 by increasing cAMP levels. | ||||||
Adenosine 3′,5′-cyclic Monophosphate, N6-Benzoyl-, Sodium Salt | 30275-80-0 | sc-300167 | 10 µmol | $318.00 | 1 | |
6-Bnz-cAMP is a specific activator of PKA. Given that CMYA5 can be phosphorylated by PKA, 6-Bnz-cAMP can enhance the activity of CMYA5 by directly activating PKA. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine can activate the beta-adrenergic receptor, leading to an increase in cAMP levels and activation of the PKA pathway. Since CMYA5 can be phosphorylated by PKA, Epinephrine can enhance the activity of CMYA5 by increasing PKA activity. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist, leading to an increase in cAMP levels and activation of the PKA pathway. Given that CMYA5 can be phosphorylated by PKA, Isoproterenol can enhance the activity of CMYA5 by stimulating PKA. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is an activator of protein kinase C (PKC), which can phosphorylate CMYA5. Therefore, PMA can enhance the activity of CMYA5 by directly activating PKC. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a broad-spectrum protein kinase inhibitor, but at low concentrations, it can selectively activate PKC, which can phosphorylate CMYA5. Therefore, Staurosporine can enhance the activity of CMYA5 by selectively activating PKC. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid is an inhibitor of protein phosphatases PP1 and PP2A. By inhibiting these phosphatases, Okadaic Acid can enhance the phosphorylation state of CMYA5, thereby enhancing its activity. | ||||||