CMAH Inhibitors
CMAH inhibitors are a class of compounds that can modulate the activity or expression of the CMAH enzyme. While direct inhibitors of CMAH are not extensively reported, various chemicals can indirectly influence the enzyme's function by targeting associated cellular pathways or processes. For instance, ManNProp and 2-Deoxy-2-fluoro-D-mannose are known to interfere with sialic acid synthesis, which reduces the substrate availability for CMAH. Likewise, Tamiflu and Zanamivir, both neuraminidase inhibitors, impact sialic acid dynamics in cells, which can further influence CMAH activity.
On the cellular signaling front, inhibitors like PD98059, SB203580, and U0126 are known to target distinct MAPK pathways. These pathways are pivotal in orchestrating a range of cellular responses, and their modulation can indirectly affect CMAH. PI3K inhibitors such as Wortmannin and LY294002 target the PI3K-Akt pathway, a pathway crucial for various cell functions that can indirectly modulate CMAH. Similarly, SP600125, a JNK inhibitor, and Y-27632, a ROCK inhibitor, are also involved in cellular signaling that could play a role in the regulation of CMAH. Furthermore, Tunicamycin, which inhibits N-linked glycosylation, can influence post-translational modifications, affecting proteins related to CMAH.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
2-Cyclohexylethanol | 4442-79-9 | sc-238018 | 100 ml | $86.00 | ||
Interferes with sialic acid synthesis, potentially reducing the available substrate for CMAH. | ||||||
Oseltamivir | 196618-13-0 | sc-507283 | 100 g | $324.00 | ||
Inhibits neuraminidase, an enzyme involved in sialic acid catabolism, which can affect overall sialic acid dynamics in the cell, indirectly influencing CMAH activity. | ||||||
Zanamivir | 139110-80-8 | sc-208495 | 1 mg | $270.00 | 6 | |
Another neuraminidase inhibitor affecting sialic acid dynamics, indirectly impacting CMAH. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
An inhibitor of the MEK signaling pathway. The MEK/ERK pathway is involved in regulating various cellular processes that might indirectly influence CMAH. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
Inhibits the p38 MAPK pathway which can be linked to cellular responses that influence CMAH indirectly. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
PI3K inhibitor that affects various cellular processes. This may indirectly modulate the activity or expression of CMAH. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
Another PI3K inhibitor. By affecting the PI3K-Akt pathway, it can indirectly influence CMAH-related cellular processes. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
JNK inhibitor that can modify cellular processes and indirectly influence CMAH. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
ROCK inhibitor that modulates cell signaling, potentially indirectly affecting CMAH. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Inhibits N-linked glycosylation, potentially affecting the post-translational modification and activity of proteins related to CMAH. | ||||||