Molecular structure of Zanamivir, CAS Number: 139110-80-8
Zanamivir (CAS 139110-80-8)
See product citations (6)
Alternate Names:
4-Guanidino-Neu5Ac2en
Application:
Zanamivir is an antiviral agent and structural analog of sialic acid
CAS Number:
139110-80-8
Purity:
98%
Molecular Weight:
332.31
Molecular Formula:
C12H20N4O7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Zanamivir is an influenza viral neuraminidase inhibitor that is a structural analog of the sialic acid. By inhibiting the neuraminidase enzyme of the influenza virus, zanamivir hinders the virus′s release from infected cells, thereby limiting its spread to other cells. This mechanism of action plays a role in preventing the spread of the virus throughout the body.
Zanamivir (CAS 139110-80-8) References
- Amantadine, oseltamivir and zanamivir for the prophylaxis of influenza (including a review of existing guidance no. 67): a systematic review and economic evaluation. | Tappenden, P., et al. 2009. Health Technol Assess. 13: iii, ix-xii, 1-246. PMID: 19215705
- Oseltamivir, zanamivir and amantadine in the prevention of influenza: a systematic review. | Jackson, RJ., et al. 2011. J Infect. 62: 14-25. PMID: 20950645
- A zanamivir dimer with prophylactic and enhanced therapeutic activity against influenza viruses. | Tarbet, EB., et al. 2014. J Antimicrob Chemother. 69: 2164-74. PMID: 24777908
- Zanamivir for influenza in adults and children: systematic review of clinical study reports and summary of regulatory comments. | Heneghan, CJ., et al. 2014. BMJ. 348: g2547. PMID: 24811412
- Oseltamivir-zanamivir combination therapy suppresses drug-resistant H1N1 influenza A viruses in the hollow fiber infection model (HFIM) system. | Pires de Mello, CP., et al. 2018. Eur J Pharm Sci. 111: 443-449. PMID: 29079337
- Favipiravir and Zanamivir Cleared Infection with Influenza B in a Severely Immunocompromised Child. | Lumby, CK., et al. 2020. Clin Infect Dis. 71: e191-e194. PMID: 32124919
- Intravenous Zanamivir: A Viable Option for Critically Ill Patients With Influenza. | Slain, D. 2021. Ann Pharmacother. 55: 760-771. PMID: 33016090
- Antiviral Treatments for Influenza. | Palomba, E., et al. 2021. Semin Respir Crit Care Med. 42: 859-872. PMID: 34918326
- Zanamivir aqueous solution in severe influenza: A global Compassionate Use Program, 2009-2019. | Wang-Jairaj, J., et al. 2022. Influenza Other Respir Viruses. 16: 542-551. PMID: 34939702
- Enabling oral delivery of antiviral drugs: Double emulsion carriers to improve the intestinal absorption of zanamivir. | Debotton, N., et al. 2022. Int J Pharm. 629: 122392. PMID: 36379395
- Pharmacokinetics of zanamivir in critically ill patients undergoing continuous venovenous hemofiltration. | Wieringa, A., et al. 2023. Antivir Ther. 28: 13596535221150746. PMID: 36609161
- Alloferon and Zanamivir Show Effective Antiviral Activity against Influenza A Virus (H1N1) Infection In Vitro and In Vivo. | Lee, D., et al. 2022. Int J Mol Sci. 24: PMID: 36614125
- Slow-binding inhibition of sialidase from influenza virus. | Pegg, MS. and von Itzstein, M. 1994. Biochem Mol Biol Int. 32: 851-8. PMID: 8069234
- 4-Guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid is a highly effective inhibitor both of the sialidase (neuraminidase) and of growth of a wide range of influenza A and B viruses in vitro. | Woods, JM., et al. 1993. Antimicrob Agents Chemother. 37: 1473-9. PMID: 8363379
Inhibitor of:
Arylsulfatase B, CCDC115, CLEC-18, CMAH, CMAS, FDC-SP, HN1, Influenza A H5N1 HA, Influenza A m1, Influenza A NP, Influenza A ns1, Influenza A ns2, Influenza A pb1, Influenza A Virus Hemagglutinin, Influenza B, Influenza B NA, Influenza B NP, La Crosse Virus G1, Measles M, Mumps NP, Mx1, NDV HN, Neuramidase, from A. ureafaciens, Neuramidase, from V. cholerae, Neuraminidase, Neuraminidase, from C. perfringens, RABIF, Rubella Virus gpE1, SIAE, Sialyltransferase 10, Sialyltransferase 7B, Sialyltransferase 7D, Siglec-10, Siglec-11, Siglec-15, Siglec-9, ST8Sia III, and ST8Sia IV.Activator of:
Bunyavirus, Neu1, Neu2, Neuramidase, from A. ureafaciens, Neuramidase, from V. cholerae, Neuraminidase, from C. perfringens, and SIAE.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Zanamivir, 1 mg | sc-208495 | 1 mg | $265.00 |