Clik1 Activators
Clik1, also known as CLK1 (CDC-like kinase 1), is a serine/threonine-protein kinase involved in the regulation of splicing, playing a pivotal role in the alternative splicing of pre-mRNA. It is a member of the CDC2-like (or LAMMER) kinase family, characterized by their ability to phosphorylate serine/arginine (SR) rich domains of splicing factors. These phosphorylation events are crucial for the spliceosome assembly, the dynamic complex responsible for the removal of introns from pre-mRNA. By modifying the splicing machinery, CLK1 influences the selection of splice sites, thereby affecting the generation of diverse mRNA transcripts from a single gene. This capacity to regulate alternative splicing endows CLK1 with a critical role in various cellular processes, including cell cycle progression, differentiation, and response to stress, making it a key player in the post-transcriptional control of gene expression.
The activation of CLK1 is intricately linked to its phosphorylation status and its interaction with other cellular proteins, which collectively modulate its kinase activity and substrate specificity. Activation typically involves autophosphorylation or the phosphorylation by other kinases, which induces conformational changes enhancing its enzymatic activity. The phosphorylation of CLK1 can be regulated by cellular signals that influence its localization, stability, and interaction with splicing factors. For instance, cellular stress responses can trigger modifications in CLK1 activity, leading to changes in alternative splicing patterns that help the cell adapt to adverse conditions. Additionally, CLK1 activity is modulated by its interaction with protein phosphatases, which can dephosphorylate and thereby inactivate it, providing a reversible mechanism for the regulation of splicing. Through these mechanisms, CLK1 serves as a critical effector in the regulation of splicing, with its activation playing a fundamental role in the post-transcriptional modulation of gene expression to meet cellular needs.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cdc2-Like Kinase Inhibitor, TG003 | 300801-52-9 | sc-202528 sc-202528A | 5 mg 25 mg | $139.00 $548.00 | 6 | |
TG003 is a potent inhibitor of Clk/Sty kinases. Though primarily an inhibitor, its role in modulating Clk kinase activity could indirectly affect CLK1 function. | ||||||
Harmine | 442-51-3 | sc-202644 sc-202644A sc-202644B sc-202644C sc-202644D sc-202644E sc-202644F | 250 mg 500 mg 1 g 10 g 50 g 100 g 500 g | $53.00 $104.00 $126.00 $551.00 $1467.00 $2611.00 $11455.00 | 2 | |
Harmine is a natural compound known to inhibit DYRK1A, another kinase. By modulating related kinase activities, it could indirectly impact CLK1. | ||||||
Casein Kinase I Inhibitor, D4476 | 301836-43-1 | sc-202522 | 1 mg | $99.00 | 6 | |
D4476 is a casein kinase 1 (CK1) inhibitor. While it targets a different kinase, its effects on cellular signaling pathways might intersect with CLK1 functions. | ||||||
Indirubin-3′-monoxime | 160807-49-8 | sc-202660 sc-202660A sc-202660B | 1 mg 5 mg 50 mg | $79.00 $321.00 $671.00 | 1 | |
This compound is a known inhibitor of cyclin-dependent kinases (CDKs). By influencing CDK activity, it could indirectly affect CLK1-mediated processes. | ||||||
5-Iodotubercidin | 24386-93-4 | sc-3531 sc-3531A | 1 mg 5 mg | $153.00 $464.00 | 20 | |
This adenosine analog inhibits various kinases. Its broad activity might intersect with pathways involving CLK1. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $94.00 $265.00 | 42 | |
Roscovitine is a CDK inhibitor, potentially impacting CLK1 by modulating related kinase activities and splicing processes. | ||||||
Flavopiridol Hydrochloride | 131740-09-5 | sc-207687 | 10 mg | $317.00 | ||
As a CDK inhibitor, Flavopiridol can influence cell cycle and transcription regulation, potentially affecting CLK1-related pathways. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $43.00 $189.00 $316.00 $663.00 | 6 | |
DRB is an adenosine analog that inhibits CDK9, impacting transcription regulation and potentially intersecting with CLK1 activity. | ||||||
Kenpaullone | 142273-20-9 | sc-200643 sc-200643A sc-200643B sc-200643C | 1 mg 5 mg 10 mg 25 mg | $61.00 $153.00 $231.00 $505.00 | 1 | |
Kenpaullone, a CDK inhibitor, might indirectly influence CLK1 activity through its effects on cell cycle regulation and kinase signaling. | ||||||
SNS-032 | 345627-80-7 | sc-364621 sc-364621A | 5 mg 10 mg | $169.00 $262.00 | ||
This is a potent inhibitor of CDKs, particularly CDK2, CDK7, and CDK9. Its broad kinase inhibitory activity might indirectly affect CLK1. | ||||||