CLCA5_Clac5 Activators
The chemical activators of CLCA5, a protein acting as a chloride channel regulator, function through diverse yet specific mechanisms to enhance its activity. Dibutyryl-cAMP, for instance, acts as a cAMP analog, directly increasing the intracellular concentration of this signaling molecule, thereby potentially leading to the augmented function of CLCA5. Similar upregulation of cAMP is achieved by Forskolin, which stimulates adenylyl cyclase, and by the PDE inhibitors IBMX, PDE4 inhibitor, Milrinone, Anagrelide, Aminophylline, Rolipram, Cilostazol, and Vinpocetine, which prevent cAMP degradation, sustaining its signaling and indirectly promoting the activity of CLCA5. The upregulated cAMP signaling is crucial for the activation of CLCA5 as it modulates the chloride conductance, a vital function of the protein.
Epinephrine also plays a role in this scenario by binding to adrenergic receptors, which leads to an increase in intracellular cAMP levels, again linking to the potential enhancement of CLCA5 function. Genistein, albeit through a different mechanism as a tyrosine kinase inhibitor, may also contribute to the regulation of cellular pathways that affect the activity of chlorideThe chemical activators of CLCA5, a protein acting as a chloride channel regulator, function through diverse yet specific mechanisms to enhance its activity. Dibutyryl-cAMP, for instance, acts as a cAMP analog, directly increasing the intracellular concentration of this signaling molecule, thereby potentially leading to the augmented function of CLCA5. Similar upregulation of cAMP is achieved by Forskolin, which stimulates adenylyl cyclase, and by the PDE inhibitors IBMX, PDE4 inhibitor, Milrinone, Anagrelide, Aminophylline, Rolipram, Cilostazol, and Vinpocetine, which prevent cAMP degradation, sustaining its signaling and indirectly promoting the activity of CLCA5. The upregulated cAMP signaling is crucial for the activation of CLCA5 as it modulates the chloride conductance, a vital function of the protein.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl-cAMP, a cAMP analog, enhances the cAMP-dependent signaling pathways. CLCA5, being a chloride channel regulator, can be influenced by changes in intracellular cAMP concentration, leading to increased channel activity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, increasing intracellular cAMP levels. Elevated cAMP is known to regulate chloride channels, potentially enhancing the activity of CLCA5. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is a tyrosine kinase inhibitor which may augment cellular processes that indirectly upregulate the activity of chloride channels like CLCA5 by modulating downstream signaling molecules. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
Isobutylmethylxanthine (IBMX) inhibits phosphodiesterases, preventing cAMP degradation, which could sustain or enhance the activation of CLCA5 through elevated cAMP levels. | ||||||
Milrinone | 78415-72-2 | sc-201193 sc-201193A | 10 mg 50 mg | $165.00 $697.00 | 7 | |
Milrinone is a selective phosphodiesterase 3 inhibitor that increases cAMP levels, potentially enhancing CLCA5 activity through cAMP-dependent signaling cascades. | ||||||
Anagrelide hydrochloride | 58579-51-4 | sc-203513 sc-203513A | 10 mg 50 mg | $103.00 $587.00 | 1 | |
Anagrelide inhibits phosphodiesterase 3 and can raise cAMP levels. Increased cAMP may potentiate the activity of CLCA5 by influencing chloride conductance. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine interacts with adrenergic receptors, which can elevate intracellular cAMP, potentially leading to the activation of CLCA5 through cAMP-mediated pathways. | ||||||
Aminophylline | 317-34-0 | sc-252368 | 25 g | $37.00 | ||
Aminophylline, a phosphodiesterase inhibitor, raises intracellular cAMP by preventing its breakdown, which could indirectly increase the activity of CLCA5. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram, a selective inhibitor of PDE4, increases intracellular cAMP levels. Elevated cAMP levels may enhance the functional activity of CLCA5. | ||||||
Cilostazol | 73963-72-1 | sc-201182 sc-201182A | 10 mg 50 mg | $109.00 $322.00 | 3 | |
Cilostazol is a phosphodiesterase 3 inhibitor that increases cAMP levels. The elevated cAMP may lead to the activation of CLCA5. | ||||||