claudin-15 Inhibitors
Claudin-15 is part of the claudin family of proteins, which are integral membrane proteins and crucial components of tight junctions in epithelial and endothelial cells. Tight junctions are essential for the selective paracellular transport of ions and solutes, maintaining cell polarity, and providing a barrier function in epithelial tissues. They play a vital role in segregating the components of the apical and basolateral membrane domains of epithelial cells. Claudin-15, like other members of the claudin family, possesses unique properties that determine its specific functions in tight junctions, such as ion selectivity and barrier function.
Inhibitors targeting claudin-15 would be specialized molecules designed to modulate the function, expression, or stability of claudin-15. Given its role in tight junctions, the inhibition of claudin-15 could impact the integrity and functionality of these junctions, potentially altering the selective permeability of epithelial or endothelial barriers. Potential inhibitors might encompass small molecules that bind directly to claudin-15, disrupting its ability to form or maintain tight junctions. This could be achieved by preventing the formation of claudin-claudin homotypic or heterotypic interactions, which are central to tight junction assembly. Another approach might involve molecules that interfere with post-translational modifications of claudin-15. Such modifications can influence its activity, cellular localization, or interactions with other tight junction proteins. Furthermore, advanced molecular strategies, such as RNA interference or antisense oligonucleotides, could be employed to regulate claudin-15 expression at the genetic level. Understanding the effects of claudin-15 inhibition can offer deeper insights into the intricacies of tight junction dynamics and the broader roles of the claudin family in epithelial and endothelial physiology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Fumonisin B1 | 116355-83-0 | sc-201395 sc-201395A | 1 mg 5 mg | $117.00 $469.00 | 18 | |
Fumonisin B1 has been shown to downregulate certain claudin proteins in intestinal cells, which might impact claudin-15 expression. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein, a tyrosine kinase inhibitor, might inhibit the phosphorylation of proteins involved in tight junction assembly and maintenance. Given that claudin 15 is a tight junction protein, its proper function could be inhibited by the prevention of necessary phosphorylation events. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
S1P can modulate the expression of various claudins. It might regulate claudin-15 expression in specific cellular contexts. | ||||||
GW4869 | 6823-69-4 | sc-218578 sc-218578A | 5 mg 25 mg | $199.00 $599.00 | 24 | |
GW4869 is an inhibitor of neutral sphingomyelinase (nSMase), an enzyme involved in sphingolipid metabolism. By inhibiting nSMase, GW4869 could alter the lipid composition of cell membranes, which could, in turn, inhibit the proper incorporation and function of claudin 15 in tight junctions. | ||||||
Manumycin A | 52665-74-4 | sc-200857 sc-200857A | 1 mg 5 mg | $215.00 $622.00 | 5 | |
Manumycin A is an inhibitor of farnesyltransferase, an enzyme responsible for the post-translational modification of many proteins. By inhibiting farnesylation, Manumycin A could alter the membrane association of proteins and potentially inhibit claudin 15′s function within tight junctions. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
This glucocorticoid can modulate claudin expression in various tissues, which might influence claudin-15. | ||||||
Lovastatin | 75330-75-5 | sc-200850 sc-200850A sc-200850B | 5 mg 25 mg 100 mg | $28.00 $88.00 $332.00 | 12 | |
Lovastatin inhibits HMG-CoA reductase, which could lead to reduced cholesterol biosynthesis. Claudin 15′s interaction with membrane cholesterol is important for tight junction function, so Lovastatin could inhibit the functionality of claudin 15 by altering the cholesterol content in cell membranes. | ||||||
Cerulenin (synthetic) | 17397-89-6 | sc-200827 sc-200827A sc-200827B | 5 mg 10 mg 50 mg | $158.00 $306.00 $1186.00 | 9 | |
Cerulenin is an inhibitor of fatty acid synthase, which could lead to changes in the fatty acid composition of cell membranes. Since claudin 15 is integral to tight junctions which are dependent on membrane fluidity and composition, Cerulenin could inhibit claudin 15 function by altering the membrane environment. | ||||||
Thymosin β4 | 77591-33-4 | sc-396076 sc-396076A | 1 mg 100 mg | $134.00 $7140.00 | ||
TGF-β can modulate the expression of several claudin proteins in different cells, potentially affecting claudin-15 expression. | ||||||
Filipin III | 480-49-9 | sc-205323 sc-205323A | 500 µg 1 mg | $116.00 $145.00 | 26 | |
Filipin III binds to cholesterol, disrupting lipid rafts in cell membranes. Given that claudin 15 is associated with tight junctions, the disturbance of lipid raft integrity could inhibit the proper localization and function of claudin 15 in these structures. | ||||||