Clathrin LCB Inhibitors

Clathrin LCB inhibitors, as a chemical class, encompass a range of compounds that indirectly impact the function of Clathrin LCB. These inhibitors do not directly target Clathrin LCB but instead modulate the associated cellular processes and signaling pathways. The primary mechanism involves the inhibition of clathrin-mediated endocytosis, a crucial cellular process in which clathrin plays a pivotal role. Compounds like Dynasore and MiTMAB achieve this by inhibiting dynamin, a GTPase essential for the final scission of clathrin-coated vesicles from the plasma membrane. Pitstop 2 and Ikarugamycin operate by disrupting the assembly of clathrin on membranes, thereby hindering the formation of clathrin-coated pits essential for endocytosis.

Other members of this class function by altering upstream signaling pathways or cellular components that indirectly influence clathrin-mediated processes. For example, Tyrosphostin AG 879 and Genistein are tyrosine kinase inhibitors that modulate cellular signaling, indirectly affecting clathrin function. Similarly, Chlorpromazine and Filipin alter cellular membrane dynamics, which is crucial for the proper functioning of clathrin-mediated endocytosis. Bafilomycin A1, a V-ATPase inhibitor, impacts endosomal acidification, thereby influencing the trafficking and sorting of endocytosed material.