Clathrin LCB Activators
Clathrin LCB Activators are chemicals that enhance the functional activity of Clathrin LCB. They primarily act by influencing the endocytic pathway, where Clathrin LCB plays a fundamental role. For instance, Dynasore and MiTMAB, by inhibiting dynamin's GTPase activity, interfere with the formation of clathrin-coated vesicles. This disruption may create a cellular response that increases the demand for clathrin, thereby enhancing the activity of Clathrin LCB. The similar mechanism is seen with the use of Pitstop 2, Chlorpromazine, and Monodansylcadaverine, which inhibit clathrin-mediated endocytosis and could thereby increase the demand for clathrin to compensate for inhibited endocytosis, enhancing Clathrin LCB activity.
Furthermore, Phenylarsine Oxide inhibits the uncoating of clathrin-coated vesicles, which could also increase the demand for clathrin in the cell. Compounds like Genistein, Wortmannin, LY294002, and 3-Methyladenine, which exert their effects by inhibiting PI3K, disrupt vesicular trafficking and may enhance Clathrin LCB activity by increasing the demand for clathrin-mediated endocytosis. Lastly, Sucrose and Potassium influence endocytosis, potentially enhancing Clathrin LCB activity as the cell attempts to compensate for changes in the endocytic pathway. Hence, these chemicals can indirectly enhance Clathrin LCB activity by influencing specific biological processes that it is directly involved in.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Phenylarsine oxide | 637-03-6 | sc-3521 | 250 mg | $40.00 | 4 | |
Phenylarsine Oxide inhibits the uncoating of clathrin-coated vesicles, which could increase Clathrin LCB activity by creating a greater need for clathrin in the cell. | ||||||
Sucrose | 57-50-1 | sc-204311 sc-204311B sc-204311C sc-204311A | 0.5 kg 50 kg 100 kg 5 kg | $57.00 $1224.00 $1760.00 $195.00 | 6 | |
Sucrose is known to inhibit endocytosis, which could enhance Clathrin LCB activity as the cell attempts to compensate for the inhibited endocytosis. | ||||||
Potassium | 7440-09-7 | sc-253297 | 1 g | $122.00 | ||
High potassium levels can stimulate the formation of clathrin-coated pits, potentially enhancing Clathrin LCB activity. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein inhibits tyrosine kinases, potentially disrupting vesicular trafficking and, in turn, increasing Clathrin LCB activity. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin inhibits PI3K, which plays a role in vesicle trafficking. This could enhance Clathrin LCB activity by increasing demand for clathrin-mediated endocytosis. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 inhibits PI3K, potentially disrupting vesicular trafficking and increasing Clathrin LCB activity. | ||||||
Autophagy Inhibitor, 3-MA | 5142-23-4 | sc-205596 sc-205596A | 50 mg 500 mg | $56.00 $256.00 | 113 | |
3-Methyladenine inhibits PI3K, potentially disrupting vesicular trafficking and thereby increasing Clathrin LCB activity. | ||||||