CHST12 Activators
CHST12, or Carbohydrate Sulfotransferase 12, plays a critical role in the post-translational modification of proteoglycans. This enzyme specifically catalyzes the transfer of sulfate groups to the glycosaminoglycan dermatan sulfate, a process which is essential for modulating the structural and functional properties of the extracellular matrix. The extracellular matrix is a complex network of proteins and carbohydrates that provides structural support to cells and tissues and facilitates communication between cells. CHST12-mediated sulfation of dermatan sulfate is crucial for a myriad of biological processes, including cellular adhesion, proliferation, and differentiation. Since the expression of CHST12 is a finely tuned process, it is subject to regulation by various endogenous and exogenous factors. Understanding the compounds that can induce the expression of CHST12 is important for comprehending how cells adapt to different biochemical environments and maintain their extracellular matrices.
Several chemical compounds have been identified as potential activators of CHST12 expression, each acting through distinct molecular mechanisms. Compounds such as epigallocatechin gallate (EGCG) and sulforaphane are known to engage with cellular antioxidant defense systems. These systems, when activated, can lead to an upsurge in the expression of a variety of genes, including those involved in the modification of the extracellular matrix components such as CHST12. Other compounds, like retinoic acid and vitamin D3, interact with nuclear receptors to stimulate gene expression in a manner that supports cell differentiation and matrix formation. Butyrate, through its epigenetic modulating activities, can enhance the transcription of genes by affecting chromatin accessibility. Forskolin, by elevating cAMP, can trigger a signaling cascade resulting in increased gene transcription. Each of these compounds, while diverse in structure and origin, shares the common potential to upregulate CHST12 expression, thereby influencing the landscape of the extracellular matrix.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin Gallate may upregulate CHST12 by activating cellular defense mechanisms that respond to environmental stress, leading to an increase in enzymes involved in extracellular matrix remodeling. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid could stimulate CHST12 expression during the process of cellular differentiation, where it is crucial for the proper formation and maintenance of the extracellular matrix. | ||||||
3,3′-Diindolylmethane | 1968-05-4 | sc-204624 sc-204624A sc-204624B sc-204624C sc-204624D sc-204624E | 100 mg 500 mg 5 g 10 g 50 g 1 g | $36.00 $64.00 $87.00 $413.00 $668.00 $65.00 | 8 | |
3,3'-Diindolylmethane has properties that may promote the expression of CHST12 by initiating a series of reactions within the cell that culminate in the adjustment of the extracellular matrix composition. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
DL-Sulforaphane can activate detoxification pathways and antioxidant response elements, potentially leading to the upregulation of CHST12 as part of a broader adaptation to oxidative stress. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin may stimulate CHST12 expression through its ability to enhance the cellular response to inflammatory stimuli, thereby possibly maintaining the integrity of the extracellular matrix. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol can activate sirtuins, which may lead to the upregulation of CHST12, linking to its role in cell survival pathways and maintenance of extracellular matrix health. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin increases intracellular cAMP levels, which can lead to a cascade of gene expression changes, possibly stimulating the synthesis of enzymes like CHST12. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone, a synthetic glucocorticoid, may stimulate CHST12 expression as it modulates a wide array of genes involved in anti-inflammatory processes and tissue repair mechanisms. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $30.00 $60.00 $93.00 | 27 | |
Hydrogen peroxide, as a reactive oxygen species, could induce CHST12 expression as part of the cellular adaptation to oxidative stress, possibly through transcription factor activation. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $70.00 $160.00 $290.00 | 2 | |
Cholecalciferol may upregulate CHST12 by engaging vitamin D receptors that govern gene expression related to cell growth, differentiation, and extracellular matrix formation. | ||||||