CHRDL1 Activators
CHRDL1, also known as Chordin-like 1, is intricately connected to the BMP (Bone Morphogenetic Protein) signaling pathway. This interconnection means that many compounds influencing BMP signaling can also modulate the activity or expression of CHRDL1. Retinoic Acid, a compound with widespread effects on cellular signaling, can affect BMP signaling and subsequently lead to modulation of CHRDL1.
Delving deeper into the chemical activators, Palovarotene stands out as a retinoic acid receptor gamma agonist. This compound has shown capabilities to suppress BMP signaling, opening avenues for its indirect effects on CHRDL1. IWR-1-endo, on the other hand, targets the Wnt/β-catenin signaling, which has known interactions with BMP signaling. The cross-talk between these pathways means that modulation of one can have ripple effects on the other. Lastly, Vactosertib, a selective ALK5 inhibitor, also impacts TGF-β signaling. Given the interaction between BMP and TGF-β pathways, it stands as another candidate influencing CHRDL1 through its regulatory effects on these pathways.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Known to affect BMP signaling, potentially leading to modulation of CHRDL1. | ||||||
Thiazovivin | 1226056-71-8 | sc-361380 sc-361380A | 10 mg 25 mg | $284.00 $634.00 | 15 | |
Targets ALK5 and, by extension, could influence BMP signaling. | ||||||
IWR-1-endo | 1127442-82-3 | sc-295215 sc-295215A | 5 mg 10 mg | $82.00 $135.00 | 19 | |
By inhibiting Wnt/β-catenin signaling, which cross-talks with BMP signaling, this compound might indirectly modulate CHRDL1. | ||||||
EW-7197 | 1352608-82-2 | sc-507465 | 5 mg | $345.00 | ||
A selective ALK5 inhibitor, affecting TGF-β signaling. Given the cross-talk between BMP and TGF-β pathways, it might influence CHRDL1. | ||||||