Chibby 3 Inhibitors
Chibby 3 inhibitors encompass a range of chemical compounds that act on different components of the Wnt/β-catenin signaling pathway, a crucial pathway in which Chibby 3 functions as a negative regulator. These inhibitors work by various mechanisms, such as preventing the palmitoylation of Wnt proteins, which is essential for their secretion and function, thereby lowering the pathway's activity and indirectly reducing Chibby 3's role in the process. Others stabilize the axin-mediated destruction complex for β-catenin or antagonize the interaction between β-catenin and transcriptional co-activators such as CREB-binding protein or T-cell factor/lymphoid enhancer factor, leading to a decrease in β-catenin's transcriptional activity and, consequently, Chibby 3's functional influence. Some inhibitors directly target the transcriptional activity of β-catenin, thereby diminishing the expression of downstream target genes that would otherwise be modulated by Chibby 3.
Furthermore, the activity of Chibby 3 is indirectly modulated by compounds that inhibit the Hedgehog signaling pathway, a pathway known to intersect with Wnt/β-catenin signaling. Inhibition of Smoothened, a component of the Hedgehog pathway, affects the cross-talk between these pathways, ultimately influencing Chibby 3 activity. In addition, inhibitors that function by selectively killing cells with active β-catenin signaling pathways not only address aberrant signaling in disease contexts but also serve to delineate the intricate regulatory roles that Chibby 3 plays within these pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $92.00 $204.00 | 19 | |
This compound inhibits the Hedgehog signaling pathway by binding to and interfering with the activity of Smoothened, a G protein-coupled receptor-like protein. Chibby 3 is associated with the regulation of Wnt/β-catenin signaling, which can be influenced by the Hedgehog pathway through cross-talk mechanisms. Inhibition of Smoothened by this compound could, therefore, lead to the suppression of signals that indirectly enhance Chibby 3 activity. | ||||||
XAV939 | 284028-89-3 | sc-296704 sc-296704A sc-296704B | 1 mg 5 mg 50 mg | $35.00 $115.00 $515.00 | 26 | |
XAV939 is a tankyrase inhibitor that stabilizes axin by preventing its poly(ADP-ribosyl)ation, thus leading to the degradation of β-catenin, a key component of the Wnt pathway. Since Chibby 3 is known to interact with components of the Wnt signaling pathway, this compound would indirectly inhibit Chibby 3 by reducing β-catenin levels and thereby diminishing the pathway's output. | ||||||
LGK 974 | 1243244-14-5 | sc-489380 sc-489380A | 5 mg 50 mg | $352.00 $1270.00 | 2 | |
LGK 974 is a porcupine inhibitor that blocks the production of Wnt proteins by inhibiting the enzyme responsible for their palmitoylation. This results in decreased Wnt signaling, which is crucial for the modulation of Chibby 3. The reduction of Wnt signaling by LGK 974 would, therefore, inhibit the functional activity of Chibby 3 indirectly. | ||||||
β-Catenin/Tcf Inhibitor, FH535 | 108409-83-2 | sc-221398 sc-221398A | 10 mg 50 mg | $178.00 $367.00 | 7 | |
A dual inhibitor of Wnt/β-catenin and PPAR signaling. It interferes with both pathways by inhibiting β-catenin/Tcf-mediated transcription and PPARδ transcriptional activity. Given that Chibby 3 is linked to Wnt/β-catenin signaling modulation, the inhibition of this pathway would result in reduced Chibby 3 activity. | ||||||
JW 74 | 863405-60-1 | sc-507506 | 5 mg | $168.00 | ||
Affects the Wnt/β-catenin signaling by stabilizing the β-catenin destruction complex, leading to reduced levels of β-catenin in the nucleus and consequently less TCF/LEF-mediated transcription. | ||||||
Salinomycin | 53003-10-4 | sc-253530 sc-253530C sc-253530A sc-253530B | 5 mg 10 mg 25 mg 100 mg | $159.00 $236.00 $398.00 $465.00 | 1 | |
Salinomycin is known to inhibit Wnt/β-catenin signaling by selectively killing β-catenin-positive cancer stem cells. The reduction of β-catenin levels would lead to a decrease in the Wnt signaling output, which would indirectly inhibit the role of Chibby 3 in this pathway. | ||||||
PRI-724 | 1422253-38-0 | sc-507535 | 25 mg | $255.00 | ||
A CBP/β-catenin antagonist that inhibits the interaction between CBP and β-catenin, leading to decreased Wnt/β-catenin signaling. Chibby 3, being a regulator within this signaling pathway, would have its activity indirectly inhibited by the reduction in β-catenin-mediated transcription caused this compound. | ||||||
Calphostin C | 121263-19-2 | sc-3545 sc-3545A | 100 µg 1 mg | $336.00 $1642.00 | 20 | |
This compound is a selective antagonist of the Tcf/β-catenin complex, leading to the inhibition of the Wnt/β-catenin pathway. The inhibition of Tcf/β-catenin-dependent transcription would result in the indirect inhibition of Chibby 3, which functions as part of this signaling cascade. | ||||||
KY02111 | 1118807-13-8 | sc-397043 sc-397043A | 5 mg 25 mg | $79.00 $336.00 | ||
Promotes the degradation of β-catenin by inhibiting Wnt-mediated signaling. As a result, the Wnt/β-catenin pathway, which Chibby 3 is known to regulate, would be inhibited, leading to decreased activity of Chibby 3. | ||||||
PNU-74654 | 113906-27-7 | sc-258020 sc-258020A | 5 mg 25 mg | $128.00 $485.00 | 7 | |
PNU-74654 is an inhibitor of the Wnt/β-catenin signaling pathway by disrupting the β-catenin/TCF interaction, without affecting β-catenin levels. This disruption would lead to the inhibition of the transcriptional activity of β-caten, and therefore inhibit Chibby 3. | ||||||