CES3 Activators
The CES3 Activators are a chemical class that modulates the CES3 enzyme, a critical player in fatty acid metabolism and drug metabolism. These activators operate through various cellular mechanisms that can lead to increased CES3 activity. 4-Methylumbelliferone and Indomethacin function by decreasing the levels of molecules that normally inhibit CES3 activity. 4-Methylumbelliferone reduces hyaluronic acid synthesis, which indirectly enhances CES3 activity, given that higher hyaluronic acid levels typically suppress CES3 function. Indomethacin, as a COX inhibitor, curtails the production of prostaglandins, which normally dampen CES3 activity.
Another key group of CES3 activators is the PPAR agonists, which include Troglitazone, Fenofibrate, Rosiglitazone, Pioglitazone, GW7647, GW1929, and WY-14643. These compounds, by binding to and activating PPARα or PPARγ, can boost CES3 expression, thereby enhancing its activity. PPARs are nuclear hormone receptors that regulate gene expression, and their activation leads to increased CES3 transcription. Dexamethasone, a glucocorticoid receptor agonist, also enhances CES3 activity by elevating its expression. The glucocorticoid receptor, when activated, can upregulate a variety of genes, including CES3. Finally, Metformin and AICAR activate AMPK, which can indirectly lead to CES3 activation. AMPK activation spurs upregulation of PPARα, a known CES3 activator.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
4-Methylumbelliferone | 90-33-5 | sc-206910 sc-206910A sc-206910B sc-206910C sc-206910D | 25 g 100 g 250 g 1 kg 2.5 kg | $34.00 $55.00 $138.00 $423.00 $954.00 | 2 | |
4-Methylumbelliferone is a hyaluronic acid synthesis inhibitor. Deceleration of hyaluronic acid synthesis can lead to the elevation of CES3 enzyme activity, as increased hyaluronic acid levels are known to decrease CES3 activity. | ||||||
Indomethacin | 53-86-1 | sc-200503 sc-200503A | 1 g 5 g | $28.00 $37.00 | 18 | |
Indomethacin is a nonselective inhibitor of cyclooxygenase (COX) enzymes. By inhibiting COX enzymes, it can reduce the production of prostaglandins which can indirectly elevate CES3 activity, since prostaglandins can inhibit CES3 activity. | ||||||
Troglitazone | 97322-87-7 | sc-200904 sc-200904B sc-200904A | 5 mg 10 mg 25 mg | $108.00 $200.00 $426.00 | 9 | |
Troglitazone is a PPARγ agonist. Activation of PPARγ has been shown to increase CES3 expression levels, thereby elevating CES3 enzyme activity. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone is a glucocorticoid receptor agonist. Activation of the glucocorticoid receptor can increase CES3 expression levels, thereby enhancing CES3 enzyme activity. | ||||||
Fenofibrate | 49562-28-9 | sc-204751 | 5 g | $40.00 | 9 | |
Fenofibrate is a PPARα agonist. Activation of PPARα can increase CES3 expression and thereby enhance CES3 enzyme activity. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $118.00 $320.00 $622.00 $928.00 $1234.00 | 38 | |
Rosiglitazone is a PPARγ agonist. By activating PPARγ, it can increase CES3 expression and thereby enhance CES3 enzyme activity. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $54.00 $123.00 | 13 | |
Pioglitazone is a PPARγ agonist. Activation of PPARγ can increase CES3 expression levels, thereby enhancing CES3 enzyme activity. | ||||||
GW 7647 | 265129-71-3 | sc-203068A sc-203068 sc-203068B sc-203068C | 1 mg 5 mg 10 mg 25 mg | $48.00 $167.00 $262.00 $648.00 | 6 | |
GW7647 is a highly selective PPARα agonist. Activation of PPARα can increase CES3 expression levels, thereby enhancing CES3 enzyme activity. | ||||||
GW 9662 | 22978-25-2 | sc-202641 | 5 mg | $68.00 | 30 | |
GW1929 is a potent and selective PPARγ agonist. Activation of PPARγ can increase CES3 expression levels, and therefore enhance CES3 enzyme activity. | ||||||
WY 14643 | 50892-23-4 | sc-203314 | 50 mg | $133.00 | 7 | |
WY-14643 is a potent PPARα agonist. Activation of PPARα can increase CES3 expression levels, thereby enhancing CES3 enzyme activity. | ||||||