CENP-L Activators
The term CENP-L Activators refers to a specific category of chemical compounds designed to modulate the activity of the CENP-L gene or protein. CENP-L, also known as Centromere Protein L, is a gene that encodes a protein associated with the centromere, a crucial region of the chromosome involved in chromosome segregation during cell division. Centromeres play a pivotal role in ensuring that genetic material is accurately distributed to daughter cells. Activators within the CENP-L Activators class are typically small molecules or chemical agents strategically engineered to interact with the CENP-L gene or protein, with the aim of enhancing its expression or influencing its functional capabilities. These activators serve as valuable tools for researchers to manipulate CENP-L-related processes and explore its potential functions within the context of cell division and chromosome segregation.
The mechanism of action for CENP-L Activators may encompass different levels of gene regulation. These compounds could influence the binding of transcription factors to the CENP-L gene promoter region, potentially increasing its transcriptional activity and leading to elevated CENP-L gene expression. Alternatively, they might affect post-translational modifications or interactions of the CENP-L protein, such as phosphorylation or protein-protein interactions, which can modulate its stability, function, or subcellular localization within the cell. Researchers and scientists employ CENP-L Activators in molecular and cellular biology studies to investigate the role of CENP-L in centromere function, chromosome segregation, and potential implications in cell division. By selectively modulating the gene's activity or protein function, researchers can gain insights into its functions, regulatory mechanisms, and potential involvement in the maintenance of genomic stability, contributing to a deeper understanding of the molecular processes involving CENP-L and its significance in cellular biology. Overall, CENP-L Activators provide valuable tools for exploring the functions and regulatory mechanisms of CENP-L in the context of centromere biology and chromosome segregation during cell division.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Paclitaxel stabilizes microtubules, disrupting normal cell division, which could lead to upregulation of CENP-L as part of a cellular attempt to stabilize kinetochore-microtubule interactions. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $173.00 $418.00 | 43 | |
Doxorubicin intercalates DNA, causing DNA damage and potentially increasing CENP-L expression as part of the DNA damage response mechanism to ensure genomic stability. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole disrupts microtubule polymerization, arresting cells in mitosis, which could lead to an upregulation of CENP-L as cells attempt to correct spindle assembly defects. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
As a DNA methyltransferase inhibitor, 5-Azacytidine could lead to changes in chromatin structure and gene expression, potentially affecting CENP-L expression in the context of altered epigenetic regulation. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $76.00 $255.00 | 18 | |
Hydroxyurea inhibits ribonucleotide reductase, causing replication stress, which might increase CENP-L expression as part of the cellular response to ensure proper chromosome segregation under stress. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid, involved in cell differentiation and growth, might influence CENP-L expression, especially in cells undergoing significant changes in their division or differentiation status. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin raises cAMP levels, potentially affecting cell cycle progression and CENP-L expression as part of cAMP-dependent signaling pathways that regulate cell division. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is an HDAC inhibitor that can alter chromatin structure and gene expression, potentially upregulating CENP-L as part of changes in transcriptional regulation during the cell cycle. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin induces ER stress by depleting ER calcium stores, potentially affecting CENP-L expression as part of the unfolded protein response linked to cell cycle regulation. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR signaling, affecting cell growth and proliferation, which could indirectly influence CENP-L expression as part of the cellular response to altered growth conditions. | ||||||