CENP-F Activators
The chemical class known as CENP-F Activators would include agents that either stabilize or destabilize microtubules, such as paclitaxel and vinblastine, respectively, both of which have been shown to arrest cells at the G2/M phase when microtubule dynamics are critical. This cell cycle arrest could potentially enhance CENP-F expression as the cell prepares for mitosis. Other compounds like UCN-01 and roscovitine are kinase inhibitors that lead to checkpoint activation, which could also result in the upregulation of CENP-F. Additionally, inhibitors of nucleotide synthesis such as 5-fluorouracil could indirectly lead to increased CENP-F expression as part of a compensatory cellular response to stalled replication forks.
Moreover, compounds targeting the mTOR pathway, such as rapamycin, could lead to alterations in cell cycle progression, potentially increasing the expression of CENP-F. DNA damaging agents like etoposide that trigger G2/M checkpoint arrest might also indirectly enhance CENP-F levels. Lastly, the modulation of chromatin structure through inhibitors of histone deacetylases, such as Trichostatin A, could affect the expression of a range of genes involved in cell cycle regulation, potentially including CENP-F.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Stabilizes microtubules, arresting cells in the G2/M phase, potentially increasing CENP-F levels due to the prolonged mitotic signaling. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $100.00 $230.00 $450.00 $1715.00 $2900.00 | 4 | |
Inhibits microtubule formation, leading to cell cycle arrest in the M phase, which can indirectly cause accumulation of CENP-F as the cell prepares for mitosis. | ||||||
UCN-01 | 112953-11-4 | sc-202376 | 500 µg | $246.00 | 10 | |
Inhibits protein kinase C, impacting cell cycle progression and potentially leading to an increase in CENP-F levels as cells are arrested in the G2/M phase. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $36.00 $149.00 | 11 | |
Induces a G1/S cell cycle arrest, creating a potential compensatory upregulation of CENP-F as the cells eventually attempt to progress through the cell cycle. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $92.00 $260.00 | 42 | |
A cyclin-dependent kinase inhibitor that leads to cell cycle arrest; could potentially increase CENP-F expression as part of the cell's response to checkpoint activation. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Causes DNA damage, leading to cell cycle arrest at the G2/M checkpoint, which could increase the expression of CENP-F as part of the DNA damage response. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $98.00 $315.00 $2244.00 $4396.00 $17850.00 $34068.00 | 3 | |
Binds to tubulin, preventing microtubule polymerization, and leads to mitotic arrest, which could cause upregulation of CENP-F. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
An HDAC inhibitor that leads to changes in chromatin structure, potentially influencing gene expression profiles, including those related to cell cycle regulation and possibly CENP-F expression. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Disrupts microtubule polymerization, causing mitotic arrest and could thus influence CENP-F levels indirectly. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A PI3K inhibitor, which may alter cell cycle progression and indirectly affect CENP-F expression as the cell prepares for mitosis. | ||||||