Cart (0)

CEL Inhibitors

Carboxylesterase-like (CEL) inhibitors are a class of chemical compounds that target and inhibit the activity of enzymes within the carboxylesterase family, particularly those resembling carboxylesterase-like enzymes. Carboxylesterases are a group of enzymes that catalyze the hydrolysis of ester bonds in various substrates, ranging from small molecules to complex lipids. CEL inhibitors function by binding to the active site of these enzymes, thereby blocking their catalytic activity. The inhibition mechanism can vary, involving either competitive inhibition, where the inhibitor competes with the substrate for the active site, or non-competitive inhibition, where the inhibitor binds to a different site on the enzyme, altering its conformation and reducing its activity. The chemical structure of CEL inhibitors is diverse, often featuring specific functional groups that interact with key amino acids in the enzyme's active site. These interactions typically include hydrogen bonding, hydrophobic interactions, and, in some cases, covalent bonding with the enzyme's active serine residue. The study and design of CEL inhibitors are significant in the context of understanding enzyme-substrate interactions and the broader implications of enzyme inhibition in biochemical pathways. By inhibiting CEL enzymes, researchers can elucidate the role these enzymes play in metabolic processes, including lipid metabolism and the breakdown of complex molecules. Furthermore, CEL inhibitors are often employed as tools in biochemical assays to study the kinetics and structural biology of carboxylesterases, providing insights into enzyme function, substrate specificity, and the structural basis of enzyme activity. The design of these inhibitors typically involves a thorough understanding of the enzyme's structure through techniques like X-ray crystallography or molecular modeling, which allows for the identification of key binding sites and the development of molecules with high specificity and potency.

Items 1 to 10 of 12 total

Display:

Product Name	CAS #	Catalog #	QUANTITY	Price	Citations	RATING
Lipase Inhibitor, THL	96829-58-2	sc-203108	50 mg	$52.00	7	(1)
Lipase Inhibitor, THL, operates through a unique mechanism that disrupts lipid metabolism by targeting the active site of lipases. It forms specific interactions with catalytic residues, altering the enzyme's conformation and reducing its activity. The compound exhibits a distinct kinetic profile, characterized by competitive inhibition, which allows for precise modulation of lipid hydrolysis. Its structural properties enhance binding affinity, influencing metabolic pathways and energy homeostasis.
LY 294002	154447-36-6	sc-201426 sc-201426A	5 mg 25 mg	$123.00 $400.00	148	(1)
A specific inhibitor of PI3K, a kinase involved in the Akt signaling pathway which regulates cell survival and proliferation. Inhibition of PI3K can suppress the activation of downstream proteins that may be associated with the CEL (E-4) function.
U-0126	109511-58-2	sc-222395 sc-222395A	1 mg 5 mg	$64.00 $246.00	136	(2)
Inhibits MEK1/2, key enzymes in the MAPK/ERK pathway, which controls fundamental cellular processes including growth and differentiation. MEK inhibition can attenuate the pathway′s influence on proteins analogous to CEL (E-4).
SB 203580	152121-47-6	sc-3533 sc-3533A	1 mg 5 mg	$90.00 $349.00	284	(5)
A pyridinyl imidazole compound that inhibits p38 MAP kinase, a molecule that transduces stress and inflammatory signals, possibly affecting proteins akin to CEL (E-4).
Rapamycin	53123-88-9	sc-3504 sc-3504A sc-3504B	1 mg 5 mg 25 mg	$63.00 $158.00 $326.00	233	(4)
Binds to FKBP12 and specifically inhibits mTOR, which is central to cell growth and metabolism, potentially influencing pathways involving CEL (E-4) analogs.
Wortmannin	19545-26-7	sc-3505 sc-3505A sc-3505B	1 mg 5 mg 20 mg	$67.00 $223.00 $425.00	97	(3)
A steroid metabolite that is a potent PI3K inhibitor, thereby affecting downstream signaling that might interact with CEL (E-4)-like proteins.
SP600125	129-56-6	sc-200635 sc-200635A	10 mg 50 mg	$40.00 $150.00	257	(3)
An anthrapyrazolone inhibitor of JNK, which modulates transcription factors and cytokines, thereby affecting signaling pathways where CEL (E-4)-like proteins could be implicated.
PD 98059	167869-21-8	sc-3532 sc-3532A	1 mg 5 mg	$40.00 $92.00	212	(2)
A synthetic compound that inhibits MEK, which works upstream in the MAPK/ERK pathway, altering the function of downstream effectors that may include CEL (E-4)-related proteins.
Bortezomib	179324-69-7	sc-217785 sc-217785A	2.5 mg 25 mg	$135.00 $1085.00	115	(2)
A proteasome inhibitor that can influence a wide range of cellular signaling pathways, including those that could involve CEL (E-4)-related proteins.
Triciribine	35943-35-2	sc-200661 sc-200661A	1 mg 5 mg	$104.00 $141.00	14	(1)
Specifically inhibits the Akt signaling pathway, which is pivotal for cell survival and growth, thus potentially influencing CEL (E-4)-like protein activity.

Santa Cruz Animal Health is a leading provider of animal health care products. ©2026 Santa Cruz Biotechnology Inc. All Rights Reserved.
Toll-Free: 1-800-457-3801 - Terms & Conditions | Privacy Policy | Legal
“Santa Cruz Animal Health”, “San Juan Ranch”, the San Juan Ranch logo, “UltraCruz”, “Supplement of Champions”, are registered trademarks of Santa Cruz Biotechnology, Inc. All other trademarks are the property of their respective owners.

CEL Inhibitors

Lipase Inhibitor, THL

LY 294002

U-0126

SB 203580

Rapamycin

Wortmannin

SP600125

PD 98059

Bortezomib

Triciribine