CEACAM5 Inhibitors
CEACAM5 inhibitors are a class of chemical compounds that target and modulate the activity of Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5, commonly referred to as CEACAM5. CEACAM5 is a glycoprotein that belongs to the CEACAM (Carcinoembryonic Antigen-Related Cell Adhesion Molecule) family and is primarily found on the surface of various human epithelial cells. It plays a crucial role in cell adhesion, cell signaling, and the regulation of cell growth and differentiation. CEACAM5 is also overexpressed in a variety of cancer types, particularly in colorectal, pancreatic, and lung cancers, making it an attractive target for cancer research.
CEACAM5 inhibitors are designed to specifically interact with CEACAM5, either by blocking its activity, inhibiting its expression, or modulating its downstream signaling pathways. These inhibitors may work through various mechanisms, including small molecules that bind to CEACAM5 receptors, monoclonal antibodies that target CEACAM5 proteins, or other biologically active compounds that interfere with CEACAM5-related processes. By disrupting CEACAM5 function, these inhibitors have the ability to impact tumor cell proliferation, invasion, and metastasis. Furthermore, they may be utilized as tools in laboratory research to better understand the role of CEACAM5 in cancer biology. Overall, CEACAM5 inhibitors hold promise for advancing our knowledge of cancer biology and contributing to the development of strategies for cancer management.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
This compound is a DNA methyltransferase inhibitor, reducing methylation of the CEACAM5 promoter region, which may lead to its decreased expression. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
As a histone deacetylase inhibitor, Suberoylanilide Hydroxamic Acid alters chromatin structure and potentially downregulates CEACAM5 expression. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 18 | |
Sodium Butyrate acts as a histone deacetylase inhibitor, potentially reducing CEACAM5 expression through changes in chromatin accessibility. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
As a tyrosine kinase inhibitor, Genistein may interfere with signaling pathways that regulate CEACAM5 expression, leading to its downregulation. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol has been shown to modulate various signaling pathways and could potentially inhibit CEACAM5 expression through these mechanisms. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin has anti-inflammatory and antioxidant properties and may affect the signaling pathways that regulate CEACAM5 expression, leading to its downregulation. | ||||||
Sulindac | 38194-50-2 | sc-202823 sc-202823A sc-202823B | 1 g 5 g 10 g | $31.00 $84.00 $147.00 | 3 | |
Sulindac, a nonsteroidal anti-inflammatory drug (NSAID), may reduce CEACAM5 expression through its anti-inflammatory effects and modulation of signaling pathways. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Disulfiram can inhibit aldehyde dehydrogenase, and it has been suggested that this action may lead to the downregulation of CEACAM5 expression. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
As a major catechin in green tea, (-)-Epigallocatechin Gallate has been shown to influence various cellular pathways and may contribute to the decreased expression of CEACAM5. | ||||||
Bicalutamide | 90357-06-5 | sc-202976 sc-202976A | 100 mg 500 mg | $41.00 $143.00 | 27 | |
Bicalutamide is an androgen receptor antagonist, and it may reduce CEACAM5 expression through its effects on androgen-regulated signaling pathways. | ||||||