CDV3 Activators
CDV3 activators encompass a varied class of chemical compounds that enhance the functional activity of CDV3 through diverse yet specific biochemical pathways. Forskolin, Isoproterenol, Epinephrine, PGE2, IBMX, and Rolipram all elevate intracellular cAMP, a critical secondary messenger that activates PKA. PKA, in turn, phosphorylates downstream targets within the signaling cascade that CDV3 is a part of, leading to its activation. The specificity of this activation is rooted in the fact that PKA directly phosphorylates substrates involved in CDV3's pathway, rather than exerting a broad-spectrum effect. Additionally, the PDE inhibitors, including IBMX, Sildenafil citrate, Zaprinast, and Rolipram, prevent the degradation of cyclic nucleotides, thereby enhancing the signaling that converges on CDV3 activation.
On another front, PMA and Anisomycin activate protein kinases such as PKC and stress-activated protein kinases, respectively. These kinases phosphorylate proteins within the signaling networks that are directly involved with CDV3, thus indirectly leading to its enhanced activity. Moreover, the calcium ionophores Ionomycin and A23187 increase intracellular calcium levels, which activate calmodulin-dependent kinases capable of interacting with CDV3's signaling pathway. Through these mechanistic actions, these compounds ensure that CDV3activity is heightened through phosphorylation events that are central to its functional role in cellular signaling.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Adenylyl cyclase activator Forskolin increases intracellular cAMP levels, which enhances the PKA pathway. CDV3, being a downstream effector in the PKA pathway, is activated through phosphorylation by PKA | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC), which can then phosphorylate substrates that are part of CDV3's activation cascade, leading to its enhanced activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Calcium ionophore Ionomycin elevates intracellular Ca2+ concentration, indirectly activating calmodulin-dependent kinases which can phosphorylate and activate proteins in the CDV3 pathway. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Beta-adrenergic agonist Isoproterenol increases cAMP levels, similarly to Forskolin, enhancing the PKA pathway and thereby potentially increasing CDV3 activity through phosphorylation. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine binds to adrenergic receptors, leading to activation of adenylyl cyclase and increased cAMP levels, which in turn activates PKA and subsequently can enhance CDV3 activity. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
Prostaglandin E2 (PGE2) engages G-protein coupled receptors, leading to cAMP production and activation of PKA, which may then enhance CDV3 activity through downstream signaling. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
Phosphodiesterase inhibitor 3-Isobutyl-1-methylxanthine (IBMX) prevents cAMP degradation, thus potentiating the PKA pathway and potentially enhancing the activity of CDV3. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Protein synthesis inhibitor Anisomycin has been shown to activate stress-activated protein kinases, which could lead to the phosphorylation and activation of proteins in the CDV3 signaling pathway. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
Calcium ionophore A23187 facilitates the influx of Ca2+, which may activate calmodulin-dependent kinases that influence the CDV3 activation pathway. | ||||||
Zaprinast (M&B 22948) | 37762-06-4 | sc-201206 sc-201206A | 25 mg 100 mg | $103.00 $245.00 | 8 | |
PDE inhibitor Zaprinast increases cGMP levels, which might activate kinases that phosphorylate proteins within the same signaling networks as CDV3, enhancing its activity. | ||||||