CDRT15L Activators
Chemical activators of CDRT15L include a variety of compounds that engage distinct biochemical pathways to promote the protein's functional state. Adenosine triphosphate (ATP) is a primary energy source that can activate CDRT15L through phosphorylation processes, which are essential for many proteins to become functionally active. Similarly, magnesium chloride provides magnesium ions, crucial cofactors for many cellular processes, including those that may be needed for CDRT15L to achieve its active conformation. Sodium fluoride acts by maintaining CDRT15L in a phosphorylated state through the inhibition of phosphatase enzymes, preventing the deactivation of the protein. Phorbol 12-myristate 13-acetate (PMA) and 1,2-Dioctanoyl-sn-glycerol (DiC8) both serve as activators of protein kinase C (PKC), which is known to phosphorylate target proteins like CDRT15L, leading to their activation.
In parallel, forskolin drives the activation of CDRT15L by increasing cyclic AMP (cAMP) levels, which in turn activates protein kinase A (PKA), a kinase that can phosphorylate and activate the protein. Ionomycin elevates intracellular calcium levels, triggering calcium-dependent kinases that may phosphorylate CDRT15L. Calmodulin, by activating calmodulin-dependent kinases, also contributes to the activation of CDRT15L through phosphorylation. Okadaic acid, on the other hand, preserves the phosphorylated state of CDRT15L by inhibiting phosphatases, ensuring sustained activation of the protein. Epidermal growth factor (EGF) stimulates its receptor and associated downstream signaling pathways, which can include kinases that target CDRT15L for activation. Additionally, hydrogen peroxide serves as a signaling molecule that can activate kinases which, in turn, activate CDRT15L through redox-mediated signaling pathways. Lastly, lithium chloride indirectly supports the activation of CDRT15L by inhibiting glycogen synthase kinase-3 (GSK-3), a negative regulator of several signaling pathways, potentially leading to an environment conducive to CDRT15L activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Adenosine 5′-Triphosphate, disodium salt | 987-65-5 | sc-202040 sc-202040A | 1 g 5 g | $38.00 $74.00 | 9 | |
ATP can activate CDRT15L by serving as a substrate for energy transfer during the activation process of CDRT15L's associated pathways, such as phosphorylation events that lead to conformational changes and activation of the protein. | ||||||
Magnesium chloride | 7786-30-3 | sc-255260C sc-255260B sc-255260 sc-255260A | 10 g 25 g 100 g 500 g | $27.00 $34.00 $47.00 $123.00 | 2 | |
Magnesium chloride provides magnesium ions, which are often required as cofactors for proteins like CDRT15L, enabling them to adopt active conformations necessary for function. | ||||||
Sodium Fluoride | 7681-49-4 | sc-24988A sc-24988 sc-24988B | 5 g 100 g 500 g | $39.00 $45.00 $98.00 | 26 | |
Sodium fluoride can activate CDRT15L by inhibiting phosphatases that would otherwise dephosphorylate the protein, thereby maintaining CDRT15L in a phosphorylated, active state. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC) which can subsequently phosphorylate CDRT15L, leading to its activation. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing cAMP levels, which can lead to activation of protein kinase A (PKA) and subsequent phosphorylation and activation of CDRT15L. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin increases intracellular calcium concentration, which can activate calcium-dependent protein kinases that phosphorylate and activate CDRT15L. | ||||||
Calmodulin (human), (recombinant) | 73298-54-1 | sc-471287 | 1 mg | $232.00 | ||
Calmodulin activates calmodulin-dependent protein kinases which can then phosphorylate and activate CDRT15L. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid acts as a potent inhibitor of protein phosphatases 1 and 2A, preventing dephosphorylation and thus maintaining CDRT15L in an active state. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $30.00 $60.00 $93.00 | 27 | |
Hydrogen peroxide can act as a signaling molecule that activates protein kinases capable of modifying and activating CDRT15L through oxidative signaling pathways. | ||||||
1,2-Dioctanoyl-sn-glycerol | 60514-48-9 | sc-202397 sc-202397A | 10 mg 50 mg | $46.00 $249.00 | 2 | |
DiC8 activates PKC which can then phosphorylate and activate CDRT15L. | ||||||